Contraceptive effect of a gonadotropin-releasing hormone vaccine on a captive female African Lion (Panthera leo): a case study

Lions (Panthera leo) breed well under captivity, so contraception has been commonly conducted for population management, leading to a demand for a less invasive and reversible contraceptive approach in lions. In this study, we examined the efficacy of a commercial gonadotropin-releasing hormone vacc...

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Published inJournal of Veterinary Medical Science Vol. 83; no. 9; pp. 1454 - 1458
Main Authors KAWASE, Keisuke, TOMIYASU, Jumpei, BAN, Kazuyuki, ONO, Ryosuke, ANDO, Satoshi, ONO, Aya, KIMURA, Ran, TOMISAWA, Kanako, MATSUI, Motozumi, SHIIHARA, Shun-ichi
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2021
The Japanese Society of Veterinary Science
Subjects
Animals
contraception
Contraceptive Agents
Estrous Cycle
Female
Gonadotropin-Releasing Hormone
gonadotropin-releasing hormone vaccine
husbandry training
immunocontraception
Lions
Vaccines
Wildlife Science
immunocontraception
gonadotropin-releasing hormone vaccine
husbandry training
contraception
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Summary:Lions (Panthera leo) breed well under captivity, so contraception has been commonly conducted for population management, leading to a demand for a less invasive and reversible contraceptive approach in lions. In this study, we examined the efficacy of a commercial gonadotropin-releasing hormone vaccine as a method of suppressing reproductive activity in a sexually matured female lion. Under behavioral restraint, the vaccine was injected twice (days 0 and 109). After the initial vaccination, ovarian activity is still observed. After the second vaccination, contraceptive effect was confirmed for 246 days until restart of estrous cycles. We confirmed only a slight swelling around the injection site after the second vaccination. This study may suggest an alternative option for a contraceptive method in lions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.21-0032