肥胖儿童糖负荷后血糖和胰岛素分泌特点及胰岛β细胞功能预测分析
目的分析肥胖儿童糖负荷后血糖、胰岛素分泌特点及胰岛素抵抗（IR）情况，以预测评估胰岛β细胞功能状态。方法将635例肥胖儿童按血糖水平分为血糖正常组（NGT组，483例）、糖调节受损组（IGR组，112例）和初发2型糖尿病组（DM组，40例）；按BMI水平分为肥胖1组（23kg/m2≤BMI＜30kg/m2，393例），肥胖2组（BMI≥30kg/m2，242例）。测定空腹及糖负荷后0.5h、1h、2h、3h血糖（FPG、0.5h-PG、1h-PG、2h-PG、3h-PG）和胰岛素水平（FINS、0.5h-INS、1h-INS、2h-INS、3h-INS），并计算胰岛素抵抗指数（HOMA-IR）...
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| Published in | 天津医药 Vol. 44; no. 12; pp. 1468 - 1472 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
天津医科大学研究生院 邮编300070%天津医科大学总医院儿科
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-9896 |
| DOI | 10.11958/20160570 |
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| Abstract | 目的分析肥胖儿童糖负荷后血糖、胰岛素分泌特点及胰岛素抵抗（IR）情况，以预测评估胰岛β细胞功能状态。方法将635例肥胖儿童按血糖水平分为血糖正常组（NGT组，483例）、糖调节受损组（IGR组，112例）和初发2型糖尿病组（DM组，40例）；按BMI水平分为肥胖1组（23kg/m2≤BMI＜30kg/m2，393例），肥胖2组（BMI≥30kg/m2，242例）。测定空腹及糖负荷后0.5h、1h、2h、3h血糖（FPG、0.5h-PG、1h-PG、2h-PG、3h-PG）和胰岛素水平（FINS、0.5h-INS、1h-INS、2h-INS、3h-INS），并计算胰岛素抵抗指数（HOMA-IR）、总体胰岛素敏感指数（WBISI）、胰岛细胞功能指数（HOMA-β）、早期胰岛素分泌指数（ΔI30/ΔG30）、胰岛素曲线下面积（AUCI）。结果IGR组各时间点胰岛素水平均高于NGT组，DM组在0.5h、1h和2h的胰岛素水平低于IGR组（均P＜0.05）。与NGT组比较，IGR组AUCI、HOMA-IR和HOMA-β升高，WBISI和ΔI30/ΔG30降低（均P＜0.05）；DM组HOMA-IR升高，WBISI、HOMA-β和ΔI30/ΔG30降低（均P＜0.05）；DM组AUCI、HOMA-β和ΔI30/ΔG30均低于IGR组（均P＜0.05）。肥胖2组FINS、AUCI、HOMA-IR、2h-PG、HOMA-β均高于肥胖1组，WBISI低于肥胖1组（均P＜0.05）；2组间FPG和ΔI30/ΔG30差异均无统计学意义。结论肥胖儿童从NGT、IGR到DM发展过程中，存在胰岛素分泌高峰后延，IR程度加重，胰岛β细胞功能代偿并最终减退。 |
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| AbstractList | R725.8; 目的：分析肥胖儿童糖负荷后血糖、胰岛素分泌特点及胰岛素抵抗（IR）情况，以预测评估胰岛β细胞功能状态。方法将635例肥胖儿童按血糖水平分为血糖正常组（NGT组，483例）、糖调节受损组（IGR组，112例）和初发2型糖尿病组（DM组，40例）；按BMI水平分为肥胖1组（23 kg/m2≤BMI＜30 kg/m2，393例），肥胖2组（BMI≥30 kg/m2，242例）。测定空腹及糖负荷后0.5 h、1 h、2 h、3 h血糖（FPG、0.5 h-PG、1 h-PG、2 h-PG、3 h-PG）和胰岛素水平（FINS、0.5 h-INS、1 h-INS、2 h-INS、3 h-INS），并计算胰岛素抵抗指数（HOMA-IR）、总体胰岛素敏感指数（WBISI）、胰岛细胞功能指数（HOMA-β）、早期胰岛素分泌指数（ΔI30/ΔG30）、胰岛素曲线下面积（AUCI）。结果 IGR组各时间点胰岛素水平均高于NGT组，DM组在0.5 h、1 h和2 h的胰岛素水平低于IGR组（均P＜0.05）。与NGT组比较， IGR组AUCI、HOMA-IR和HOMA-β升高，WBISI和ΔI30/ΔG30降低（均P＜0.05）；DM组HOMA-IR升高，WBISI、HOMA-β和ΔI30/ΔG30降低（均P＜0.05）；DM组AUCI、HOMA-β和ΔI30/ΔG30均低于IGR组（均P＜0.05）。肥胖2组FINS、AUCI、HOMA-IR、2 h-PG、HOMA-β均高于肥胖1组，WBISI低于肥胖1组（均P＜0.05）；2组间FPG和ΔI30/ΔG30差异均无统计学意义。结论肥胖儿童从NGT、IGR到DM发展过程中，存在胰岛素分泌高峰后延，IR程度加重，胰岛β细胞功能代偿并最终减退。 目的分析肥胖儿童糖负荷后血糖、胰岛素分泌特点及胰岛素抵抗（IR）情况，以预测评估胰岛β细胞功能状态。方法将635例肥胖儿童按血糖水平分为血糖正常组（NGT组，483例）、糖调节受损组（IGR组，112例）和初发2型糖尿病组（DM组，40例）；按BMI水平分为肥胖1组（23kg/m2≤BMI＜30kg/m2，393例），肥胖2组（BMI≥30kg/m2，242例）。测定空腹及糖负荷后0.5h、1h、2h、3h血糖（FPG、0.5h-PG、1h-PG、2h-PG、3h-PG）和胰岛素水平（FINS、0.5h-INS、1h-INS、2h-INS、3h-INS），并计算胰岛素抵抗指数（HOMA-IR）、总体胰岛素敏感指数（WBISI）、胰岛细胞功能指数（HOMA-β）、早期胰岛素分泌指数（ΔI30/ΔG30）、胰岛素曲线下面积（AUCI）。结果IGR组各时间点胰岛素水平均高于NGT组，DM组在0.5h、1h和2h的胰岛素水平低于IGR组（均P＜0.05）。与NGT组比较，IGR组AUCI、HOMA-IR和HOMA-β升高，WBISI和ΔI30/ΔG30降低（均P＜0.05）；DM组HOMA-IR升高，WBISI、HOMA-β和ΔI30/ΔG30降低（均P＜0.05）；DM组AUCI、HOMA-β和ΔI30/ΔG30均低于IGR组（均P＜0.05）。肥胖2组FINS、AUCI、HOMA-IR、2h-PG、HOMA-β均高于肥胖1组，WBISI低于肥胖1组（均P＜0.05）；2组间FPG和ΔI30/ΔG30差异均无统计学意义。结论肥胖儿童从NGT、IGR到DM发展过程中，存在胰岛素分泌高峰后延，IR程度加重，胰岛β细胞功能代偿并最终减退。 |
| Abstract_FL | Objective To investigate the characteristics of plasma glucose, insulin secretion and changes of insulin resistance (IR) after a glucose load in obese children, and to predict islet β-cell function. Methods A total of 635 obese children were classified into normal glucose tolerance (NGT) group (n=483), impaired glucose regulation (IGR) group (n=112) and type 2 diabetes mellitus (DM) group (n=40) based on their glucose levels. Subjects were also divided into G1 group (23 kg/m2≤BMI<30 kg/m2, n=393) and G2 group (BMI≥30 kg/m2, n=242) based on their different BMI levels. Level of fast plasma glucose (FPG, 0.5 h-PG, 1 h-PG, 2 h-PG and 3 h-PG) and insulin (FINS, 0.5 h-INS, 1 h-INS, 2 h-INS and 3 h-INS) were measured 0 h, 0.5 h, 1 h, 2 h and 3 h after a glucose load. Insulin resistance index (HOMA-IR), whole body insulin sensitivity index (WBISI), function of pancreatic beta-cell (HOMA-β), first-phase insulin secretion index (ΔI30/ΔG30) and area under curve of insulin (AUCI) were calculated and compared between groups. Results The value of insulin at each time point was significantly higher in IGR group than that of NGT group. The values of insulin at 0.5 h, 1 h, and 2 h were significantly lower in DM group than those of IGR group, respectively (all P<0.05). Compared with NGT group, AUCI, HOMA-IR and HOMA-β increased, but WBISI and ΔI30/ΔG30 decreased in IGR group (all P<0.05). HOMA-IR increased but WBISI, HOMA-βandΔI30/ΔG30 decreased in DM group (all P<0.05). Compared with IGR group, AUCI, HOMA-βandΔI30/ΔG30 decreased in DM group (all P<0.05). Values of FINS, AUCI, HOMA-IR, 2h-PG and HOMA-βwere significantly higher in G2 group than those of G1 group, but WBISI decreased (all P<0.05). There were no significant differences in FPG and ΔI30/ΔG30 between these two groups. Conclusion From NGT, IGR to DM, the peak of insulin secretion is postponed, insulin resistance is getting heavier and the compensation of insulin secretion after a glucose load is increased first and then decreased. |
| Author | 朱凯凯;刘戈力;杨箐岩;郑荣秀;鲍鹏丽;张姗姗;程炳娟 |
| AuthorAffiliation | 天津医科大学研究生院,300070;天津医科大学总医院儿科 |
| AuthorAffiliation_xml | – name: 天津医科大学研究生院 邮编300070%天津医科大学总医院儿科 |
| Author_FL | BAO Pengli LIU Geli ZHANG Shanshan ZHU Kaikai ZHENG Rongxiu YANG Qingyan CHENG Bingjuan |
| Author_FL_xml | – sequence: 1 fullname: ZHU Kaikai – sequence: 2 fullname: LIU Geli – sequence: 3 fullname: YANG Qingyan – sequence: 4 fullname: ZHENG Rongxiu – sequence: 5 fullname: BAO Pengli – sequence: 6 fullname: ZHANG Shanshan – sequence: 7 fullname: CHENG Bingjuan |
| Author_xml | – sequence: 1 fullname: 朱凯凯;刘戈力;杨箐岩;郑荣秀;鲍鹏丽;张姗姗;程炳娟 |
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| DocumentTitleAlternate | Characteristics of plasma glucose and insulin secretion after a glucose load and prediction of islet beta cell function in obese children |
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| Keywords | insulin-secreting cells blood glucose glucose tolerance test 肥胖症 血糖 胰岛素抵抗 葡糖耐量试验 糖尿病,2型 diabetes mellitus,type 2 儿童 胰岛素分泌细胞 insulin resistance obesity child |
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| Notes | obesity; blood glucose; insulin resistance; insulin- secreting cells; diabetes mellitus, type 2; glucose tolerance test; child 12-1116/R Objective To investigate the characteristics of plasma glucose, insulin secretion and changes of insulin resistance (IR) after a glucose load in obese children, and to predict islet β-cell function. Methods A total of 635 obese children were classified into normal glucose tolerance (NGT) group (n=483), impaired glucose regulation (IGR) group (n=112) and type 2 diabetes mellitus (DM) group (n=40) based on their glucose levels. Subjects were also divided into G1 group(23 kg/m2≤BMI<30 kg/m2, n=393) and G2 group (BMI≥30 kg/m2, n=242) based on their different BMI levels. Level of fastplasma glucose (FPG, 0.5 h-PG, 1 h-PG, 2 h-PG and 3 h-PG) and insulin (FINS, 0.5 h-INS, 1 h-INS, 2 h-INS and 3 h-INS) were measured 0 h, 0.5 h, 1 h, 2 h and 3 h after a glucose load. Insulin resistance index (HOMA-IR), whole bodyinsulin sensitivity index (WBISI), function of pancreatic beta-cell (HO |
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| Snippet | ... R725.8; 目的：分析肥胖儿童糖负荷后血糖、胰岛素分泌特点及胰岛素抵抗（IR）情况，以预测评估胰岛β细胞功能状态。方法将635例肥胖儿童按血糖水平分为血糖正常组（NGT组，483例）、糖调节受损组（IGR组，112例）和初发2型糖尿病组（DM组，40例）；按BMI水平分为肥胖1组（23 kg/m2≤BMI＜30... |
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| StartPage | 1468 |
| SubjectTerms | 肥胖症;血糖;胰岛素抵抗;胰岛素分泌细胞;糖尿病,2型;葡糖耐量试验;儿童 |
| Title | 肥胖儿童糖负荷后血糖和胰岛素分泌特点及胰岛β细胞功能预测分析 |
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