Buyang Huanwu decoction up-regulates Notch1 gene expression in injured spinal cord

Expression of genes in the Notch signaling pathway is altered in the injured spinal cord, which indicates that Notch participates in repair after spinal cord injury. Buyang Huanwu decoction, a traditional Chinese herbal preparation, can promote the growth of nerve cells and nerve fibers; however, it...

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Published inNeural regeneration research Vol. 10; no. 8; pp. 1321 - 1323
Main Authors Guo, Zhan-Peng, Huang, Mi-Na, Liu, An-Qi, Yuan, Ya-Jiang, Zhao, Jian-Bo, Mei, Xi-Fan
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.08.2015
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Analysis
Care and treatment
Gene expression
Genetic aspects
Insects
Laboratory animals
nerve regeneration; Buyang Huanwu decoction; spinal cord injury; Notch1 signaling pathway; Chinese medicine; neural regeneration
Notch
Spinal cord
Spinal cord injuries
Stem cells
中草药制剂
基因表达
大鼠模型
神经纤维
神经细胞
脊髓损伤
补阳还五汤
China
spinal cord injury
Chinese medicine
nerve regeneration
Notch1 signaling pathway
neural regeneration
Buyang Huanwu decoction
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Summary:Expression of genes in the Notch signaling pathway is altered in the injured spinal cord, which indicates that Notch participates in repair after spinal cord injury. Buyang Huanwu decoction, a traditional Chinese herbal preparation, can promote the growth of nerve cells and nerve fibers; however, it is unclear whether Buyang Huanwu decoction affects the Notch signaling pathway in injured spinal cord. In this study, a rat model was established by injuring the T10 spinal cord. At 2 days after injury, rats were intragastrically administered 2 m L of 0.8 g/m L Buyang Huanwu decoction daily until sacrifice. Real-time reverse transcription polymerase chain reaction analysis demonstrated that at 7, 14 and 28 days after injury, the expression of Notch1 was increased in the Buyang Huanwu decoction group compared with controls. These findings confirm that Buyang Huanwu decoction can promote the expression of Notch1 in rats with incomplete spinal cord injury, and may indicate a mechanism to promote the repair of spinal cord injury.
Bibliography:nerve regeneration Buyang Huanwu decoction spinal cord injury Notch1 signaling pathway Chinese medicine neural regeneration
Expression of genes in the Notch signaling pathway is altered in the injured spinal cord, which indicates that Notch participates in repair after spinal cord injury. Buyang Huanwu decoction, a traditional Chinese herbal preparation, can promote the growth of nerve cells and nerve fibers; however, it is unclear whether Buyang Huanwu decoction affects the Notch signaling pathway in injured spinal cord. In this study, a rat model was established by injuring the T10 spinal cord. At 2 days after injury, rats were intragastrically administered 2 m L of 0.8 g/m L Buyang Huanwu decoction daily until sacrifice. Real-time reverse transcription polymerase chain reaction analysis demonstrated that at 7, 14 and 28 days after injury, the expression of Notch1 was increased in the Buyang Huanwu decoction group compared with controls. These findings confirm that Buyang Huanwu decoction can promote the expression of Notch1 in rats with incomplete spinal cord injury, and may indicate a mechanism to promote the repair of spinal cord injury.
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These authors contributed equally to this work.
Author contributions: XFM was responsible for funding and authorized the study. ZPG, MNH, YJY, JBZ and AQL designed and performed the study, and participated in data analysis. All authors approved the final version of the paper.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.162767