Non-A Blood Type Is a Risk Factor for Poor Cardio-Cerebrovascular Outcomes in Patients Undergoing Dialysis

• Published in: Biomedicines Vol. 11; no. 2; p. 592
• Main Authors: Nakayama, Takafumi, Yamamoto, Junki, Ozeki, Toshikazu, Tsuruta, Yoshiro, Yokoi, Masashi, Aoi, Tomonori, Mori, Yoshiko, Hori, Mayuko, Tsujita, Makoto, Shirasawa, Yuichi, Kondo, Chika, Yasuda, Kaoru, Murata, Minako, Kinoshita, Yuko, Suzuki, Shigeru, Fukuda, Michio, Yamazaki, Chikao, Ikehara, Noriyuki, Sugiura, Makoto, Goto, Toshihiko, Hashimoto, Hiroya, Yajima, Kazuhiro, Maruyama, Shoichi, Morozumi, Kunio, Seo, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.02.2023; MDPI
• Subjects: ABO blood type; ABO system; Blood; Blood groups; Blood pressure; Cardiovascular disease; cardiovascular event; Cerebrovascular disease; cerebrovascular event; Chi-square test; Clinical outcomes; Diabetes; Dialysis; Flow velocity; Heart; Hemodialysis; Hemoglobin; Hemorrhage; Hospitals; Hyperlipidemia; Hypertension; Medical records; Peritoneal dialysis; Physiological aspects; Risk factors; Stroke; Values; Japan; hemodialysis; ABO blood type; cerebrovascular event; cardiovascular event
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines11020592

The clinical impact of ABO blood type on cardio-cerebrovascular outcomes in patients undergoing dialysis has not been clarified. A total of 365 hemodialysis patients participated in the current study. The primary endpoint was defined as a composite including cardio-cerebrovascular events and cardio-cerebrovascular death. The primary endpoint was observed in 73 patients during a median follow-up period of 1182 days, including 16/149 (11%) with blood type A, 22/81 (27%) with blood type B, 26/99 (26%) with blood type O, and 9/36 (25%) with blood type AB. At baseline, no difference was found in the echocardiographic parameters. Multivariable Cox regression analyses revealed that blood type (type A vs. non-A type; hazard ratio (HR): 0.46, 95% confidence interval (95% CI): 0.26-0.81, = 0.007), age (per 10-year increase; HR: 1.47, 95% CI: 1.18-1.84), antiplatelet or anticoagulation therapy (HR: 1.91, 95% CI: 1.07-3.41), LVEF (per 10% increase; HR: 0.78, 95% CI: 0.63-0.96), and LV mass index (per 10 g/m increase; HR: 1.07, 95% CI: 1.01-1.13) were the independent determinants of the primary endpoint. Kaplan-Meier curves also showed a higher incidence of the primary endpoint in the non-A type than type A (Log-rank = 0.001). Dialysis patients with blood type A developed cardio-cerebrovascular events more frequently than non-A type patients.