Biological conduit small gap sleeve bridging method for peripheral nerve injury： regeneration law of nerve fibers in the conduit

• Published in: Neural regeneration research Vol. 10; no. 1; pp. 71 - 78
• Main Authors: Zhang, Pei-Xun, Li-Ya, A, Kou, Yu-Hui, Yin, Xiao-Feng, Xue, Feng, Han, Na, Wang, Tian-Bing, Jiang, Bao-Guo
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 2015; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Apoptosis; Biocompatibility; Biotechnology; Care and treatment; Edema; Enzymes; nerve regeneration; peripheral nerve; small gap; axons; Schwann cells; repair; injury; biological conduit; NSFC grants; neural regeneration; Peripheral nervous system diseases; Risk factors; Special Issue; 再生法; 可生物降解; 周围神经损伤; 套管; 小间隙; 桥接方法; 神经纤维; 管道修复; China; Beijing China; United States > US; repair; axons; biological conduit; neural regeneration; peripheral nerve; NSFC grants; Schwann cells; nerve regeneration; small gap; injury
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.150709

The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair periph- eral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral nerve injury. This study sought to identify the regeneration law of nerve fibers in the biological conduit. A nerve regeneration chamber was constructed in models of sciatic nerve injury using 2-mm small gap sleeve bridging of a biodegradable biological conduit. The results showed that the biological conduit had good his- tocompatibility. Tissue and cell apoptosis in the conduit apparently lessened, and regenerating nerve fibers were common. The degeneration regeneration law of Schwann cells and axons in the conduit was quite different from that in traditional epineurium suture. During the prime period for nerve fiber regeneration （2-8 weeks）, the number of Schwann cells and nerve fibers was higher in both proximal and distal ends, and the effects of the small gap sleeve bridging method were better than those of the traditional epineurium suture. The above results provide an objec- tive and reliable theoretical basis for the clinical application of the biological conduit small gap sleeve bridging method to repair peripheral nerve injury.