Offering surprises: TCA cycle regulation in Corynebacterium glutamicum

Corynebacterium glutamicum, a Gram-positive soil bacterium, is used for the production of l-glutamate and l-lysine, both of which are derived from intermediates of the tricarboxylic acid (TCA) cycle. Recent studies have revealed that this amphibolic pathway is subject to complex regulation not only...

Full description

Saved in:
Bibliographic Details
Published inTrends in microbiology (Regular ed.) Vol. 15; no. 9; pp. 417 - 425
Main Author Bott, Michael
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2007
Subjects
Acetates - metabolism
Aconitate Hydratase - genetics
Amino Acid Sequence
Amino Acids - biosynthesis
Base Sequence
Citric Acid Cycle
Corynebacterium glutamicum
Corynebacterium glutamicum - metabolism
Gene Expression Regulation, Bacterial
Internal Medicine
Ketoglutarate Dehydrogenase Complex - metabolism
Molecular Sequence Data
Phosphorylation
Transcription, Genetic
Online AccessGet full text

Cover

More Information
Summary:Corynebacterium glutamicum, a Gram-positive soil bacterium, is used for the production of l-glutamate and l-lysine, both of which are derived from intermediates of the tricarboxylic acid (TCA) cycle. Recent studies have revealed that this amphibolic pathway is subject to complex regulation not only at the transcriptional level, but also at the post-transcriptional level. The latter involves serine/threonine protein kinase G and its target protein OdhI. Depending on its phosphorylation state, OdhI inhibits the 2-oxoglutarate dehydrogenase complex. This new type of TCA cycle control will be reviewed here together with regulation at the level of gene expression.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Review-3
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2007.08.004