A Synchronous Pancreatic Neuroendocrine Tumor and Duodenal Gastrointestinal Stromal Tumor

• Published in: Internal Medicine Vol. 53; no. 21; pp. 2483 - 2488
• Main Authors: Ueda, Keijiro, Hijioka, Masayuki, Lee, Lingaku, Igarashi, Hisato, Niina, Yusuke, Osoegawa, Takashi, Nakamura, Kazuhiko, Takahashi, Shunsuke, Aishima, Shinichi, Ohtsuka, Takao, Takayanagi, Ryoichi, Ito, Tetsuhide
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2014
• Subjects: Aged; Biopsy, Fine-Needle; Duodenal Neoplasms - diagnosis; Endosonography; Female; gastrointestinal stromal tumors; Gastrointestinal Stromal Tumors - diagnosis; Humans; Neoplasms, Multiple Primary - diagnosis; Neuroendocrine Tumors - diagnosis; Pancreatic Neoplasms - diagnosis; pancreatic neuroendocrine tumors; synchronous onset
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.53.2694

We recently encountered the case of a patient with a synchronous duodenal gastrointestinal stromal tumor (GIST) and pancreatic neuroendocrine tumor (PNET). This is the first report of this specific combination of multiple primary tumors, although three cases involving both PNET and gastric GIST have previously been reported. Since the duodenal GIST developed close to the pancreatic uncus in this case, we considered the possibility of multiple PNETs in the differential diagnosis. However, a histopathological examination using endoscopic ultrasonography-guided fine-needle aspiration confirmed the diagnosis of multiple primary lesions, involving PNET and duodenal GIST.