Rationale for MYC imaging and targeting in pancreatic cancer

The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The development and successful implementation of precision oncology in other gastrointestinal tu...

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Bibliographic Details
Published inEJNMMI research Vol. 11; no. 1; p. 104
Main Authors Schneider, Günter, Wirth, Matthias, Keller, Ulrich, Saur, Dieter
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 12.10.2021
Springer Nature B.V
SpringerOpen
Subjects
Advanced targeted imaging and therapy in precision oncology: A multidisciplinary challenge
Biology
Cardiac Imaging
Chemotherapy
Clinical trials
Cytokines
Imaging
Kinases
Lethality
Medical prognosis
Medical research
Medicine
Medicine & Public Health
Metastasis
MYC
Nuclear Medicine
Oncology
Orthopedics
Pancreatic cancer
Precision oncology
Radiology
Review
Subgroups
Targeted therapies
Targeted therapies
Precision oncology
Pancreatic cancer
MYC
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Summary:The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The development and successful implementation of precision oncology in other gastrointestinal tumor entities point to opportunities also for PDAC. Therefore, markers linked to specific therapeutic responses and important subgroups of the disease are needed. The MYC oncogene is a relevant driver in PDAC and is linked to drug resistance and sensitivity. Here, we update recent insights into MYC biology in PDAC, summarize the connections between MYC and drug responses, and point to an opportunity to image MYC non-invasively. In sum, we propose MYC-associated biology as a basis for the development of concepts for precision oncology in PDAC.
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SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2191-219X
2191-219X
DOI:10.1186/s13550-021-00843-1