Nanoparticles in tissue engineering: applications, challenges and prospects

• Published in: International Journal of Nanomedicine Vol. 13; pp. 5637 - 5655
• Main Authors: Hasan, Anwarul, Morshed, Mahboob, Memic, Adnan, Hassan, Shabir, Webster, Thomas J, Marei, Hany El-Sayed
• Format: Journal Article Book Review
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Antibacterial agents; Antibacterial Applications; Bacteria; Biocompatible Materials - chemistry; Biological products; Biosensing Techniques; Biosensors; Cerium oxides; Deoxyribonucleic acid; Detection equipment; DNA; Electric Conductivity; Gene Delivery; Genes; Gold; Gram-positive bacteria; Humans; Joint surgery; Mechanotransduction; Medical equipment; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Nanotechnology; Oxidative stress; Povidone; Quantum dots; Review; Tissue Engineering; Tissue Engineering - methods; United States > US; Bangladesh; Qatar; gene delivery; antibacterial applications; tissue engineering; nanoparticles; mechanotransduction
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S153758

Tissue engineering (TE) is an interdisciplinary field integrating engineering, material science and medical biology that aims to develop biological substitutes to repair, replace, retain, or enhance tissue and organ-level functions. Current TE methods face obstacles including a lack of appropriate biomaterials, ineffective cell growth and a lack of techniques for capturing appropriate physiological architectures as well as unstable and insufficient production of growth factors to stimulate cell communication and proper response. In addition, the inability to control cellular functions and their various properties (biological, mechanical, electrochemical and others) and issues of biomolecular detection and biosensors, all add to the current limitations in this field. Nanoparticles are at the forefront of nanotechnology and their distinctive size-dependent properties have shown promise in overcoming many of the obstacles faced by TE today. Despite tremendous progress in the use of nanoparticles over the last 2 decades, the full potential of the applications of nanoparticles in solving TE problems has yet to be realized. This review presents an overview of the diverse applications of various types of nanoparticles in TE applications and challenges that need to be overcome for nanotechnology to reach its full potential.