A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features

• Published in: Frontiers in physiology Vol. 9; p. 1693
• Main Authors: Santoro, Aurelia, Bazzocchi, Alberto, Guidarelli, Giulia, Ostan, Rita, Giampieri, Enrico, Mercatelli, Daniele, Scurti, Maria, Berendsen, Agnes, Surala, Olga, Jennings, Amy, Meunier, Nathalie, Caumon, Elodie, Gillings, Rachel, Kadi, Fawzi, Capel, Frederic, Cashman, Kevin D., Pietruszka, Barbara, Feskens, Edith J. M., De Groot, Lisette C. P. G. M., Battista, Giuseppe, Salvioli, Stefano, Franceschi, Claudio
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 2018; Frontiers Media S.A
• Subjects: body composition; Chair Nutrition and Health over the Lifecourse; DXA; elderly; Europe; fat; Global Nutrition; HNE Nutrition and Health over the Lifecourse; HNE Voeding en Gezondheid in de Levenscyclus; Human health and pathology; lean and bone mass; Life Sciences; Physiology; sex; Tissues and Organs; VLAG; Wereldvoeding; body composition; Europe; elderly; sex; fat; lean and bone mass; DXA
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2018.01693

Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment of BC has been studied in various populations and diseases such as obesity, diabetes, endocrine diseases as well as physiological and paraphysiological conditions such as growth and aging processes, and physical training. A gold standard technique for the assessment of human BC at molecular level is represented by dual-energy X-ray absorptiometry (DXA), which is able to precisely assess the body mass (and areal bone mineral density-aBMD) on a regional and whole-body basis. For the first time, within the framework of the NU-AGE project, BC has been assessed by means of a whole-body DXA scan in 1121 sex-balanced free-living, apparently healthy older adults aged 65-79 years enrolled in 5 European countries (Italy, France, United Kingdom, Netherlands, and Poland). The aim of this analysis is to provide a complete profile of BC in healthy elderly participants from five European countries and to investigate country- and sex-related differences by state-of-the-art DXA technology. To compare BC data collected in different centers, specific indexes and ratios have been used. Non-parametric statistical tests showed sex-specific significant differences in certain BC parameters. In particular, women have higher fat mass (FM) (Fat/Lean mass ratio: by 67%, < 2.2e-16) and lower lean mass (Lean Mass index: by -18%, < 2.2e-16) than men. On the other hand, men have higher android FM than women (Android/gynoid FM ratio: by 56%, < 2.2e-16). Interesting differences also emerged among countries. Polish elderly have higher FM (Fat/Lean mass ratio: by 52%, < 2.2e-16) and lower lean mass (Skeletal Mass index: by -23%, < 2.2e-16) than elderly from the other four countries. At variance, French elderly show lower FM (Fat/Lean mass ratio: by -34%, < 2.2e-16) and higher lean mass (Skeletal Mass index: by 18%, < 2.2e-16). Moreover, five BC profiles in women and six in men have been identified by a cluster analysis based on BC parameters. Finally, these data can serve as reference for normative average and variability of BC in the elderly populations across Europe.