Sesame oil and vitamin E co-administration may improve cardiometabolic risk factors in patients with metabolic syndrome: a randomized clinical trial

• Published in: European journal of clinical nutrition Vol. 73; no. 10; pp. 1403 - 1411
• Main Authors: Farajbakhsh, Ali, Mazloomi, Seyed Mohammad, Mazidi, Mohsen, Rezaie, Peyman, Akbarzadeh, Marzieh, Ahmad, Saeedeh Poor, Ferns, G. A., Ofori-Asenso, Richard, Babajafari, Siavash
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2019; Nature Publishing Group
• Subjects: 692/699/75; 692/700/2814; Abnormalities; alpha tocopherol; Anthropometry; biochemical marker; Biochemical markers; Blood pressure; C reactive protein; Cardiovascular diseases; Cholesterol; Clinical Nutrition; Clinical trials; Clustering; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diet; Dietary intake; Enrichment; Epidemiology; Fasting; glucose; Health risks; High density lipoprotein; high density lipoprotein cholesterol; Insulin; Internal Medicine; Lipids; Malondialdehyde; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic disorders; Metabolic syndrome; Oil; Oils & fats; Public Health; Risk analysis; Risk factors; Sensitivity analysis; Serum lipids; Sesame oil; sesamum; Sunflower oil; Sunflowers; Tocopherol; triacylglycerol; Triglycerides; Vegetable oils; Vitamin E; Iran
• ISSN: 0954-3007; 1476-5640; 1476-5640
• DOI: 10.1038/s41430-019-0438-5

Objectives Metabolic syndrome (MetS) represents a clustering of metabolic abnormalities that are associated with an increased risk of type 2 diabetes and cardiovascular disease. We aimed to evaluate the effects of sesame oil enriched with vitamin E (vit E), sesame oil alone and sunflower oil on lipid profile, fasting blood glucose (FBG), malondialdehyde (MDA), high-sensitivity C-reactive protein (Hs-CRP), homeostatic model assessment (HOMA-IR), and blood pressure (BP) in patients with MetS. Subjects Overall, 75 individuals with MetS (aged 30–70 years) participated in this randomized, single-blind controlled trial. Patients were randomly allocated to: (1) Group A ( n  = 25): sesame oil (30 ml/day) enriched with vit E (400 mg/day), (2) Group B ( n  = 25): sesame oil (30 ml/day), (3) Group C ( n  = 25): sunflower oil (30 ml/day). Anthropometric data, dietary intake, blood pressure, and biochemical markers, including fasting serum lipids, FBG, serum insulin, MDA, and hs-CRP were measured at baseline and at week 8. Results In individuals in the sesame oil enriched with vit E group (Group A), there were significant reductions in serum total cholesterol (TC), triglycerides (TG), FBG, HOMA-IR, MDA, hs-CRP, high-density lipoprotein (HDL-C) systolic and diastolic BP (for all the comparison p  < 0.02). Similarly, in Group B (taking sesame oil alone), TC, TG, FBG, HOMA-IR, MDA, systolic and diastolic BP were significantly improved (for all the comparison p  < 0.025), while there were no significant changes in serum HDL (baseline = 35.9 ± 7.2 mg/dL vs. 36.4 ± 6.2 mg/dL, p  = 0.432) and hs-CRP (baseline = 4.38 ± 1.34 mg/dL vs. week 8 = 3.96 ± 1.7 mg/dL, p  = 0.057) in second group. No significant changes in any of the studied clinical and anthropometric data were found in Group C (on sunflower oil). Conclusion Sesame oil (±vit E) was shown to beneficially affect several cardiometabolic indices (including lipids, FBG, BP, HOMA-IR, and MDA) in patients with MetS.