A New Azaphilone, Falconensin H, from Emericella falconensis

A new azaphilone derivative, falconensin H (6), was isolated from mycelia of Emericella falconensis, together with previously reported falconensins A-D (1-4) and 3, 3'-dihydroxy-5, 5'-dimethyldiphenyl ether (5). The structure of 6 was elucidated by spectroscopic investigation and chemical...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 41; no. 11; pp. 2040 - 2041
Main Authors ITABASHI, Takeshi, NOZAWA, Koohei, NAKAJIMA, Shoichi, KAWAI, Ken-ichi
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1993
Maruzen
Japan Science and Technology Agency
Subjects
3, 3'-dihydroxy-5, 5'-dimethyldiphenyl ether
antibacterial activity
azaphilone
Biological and medical sciences
Emericella falconensis
falconensin H
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Molecular structure
Bacillus subtilis
Pharmacognosy
Extract
Bacillaceae
In vitro
Biological activity
Emericella
Fungi
Antibiotic
Sensitivity resistance
Bacillales
Plant origin
Bacteria
Isolation
Ascomycetes
Antibacterial agent
Thallophyta
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Summary:A new azaphilone derivative, falconensin H (6), was isolated from mycelia of Emericella falconensis, together with previously reported falconensins A-D (1-4) and 3, 3'-dihydroxy-5, 5'-dimethyldiphenyl ether (5). The structure of 6 was elucidated by spectroscopic investigation and chemical correlations. Among the compounds isolated, only 5 showed antibacterial activity.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.41.2040