Dramatic Improvement of Diabetes Mellitus Following the Treatment of Coexisting Acromegaly and Cushing's Syndrome

• Published in: Internal Medicine Vol. 54; no. 19; pp. 2471 - 2474
• Main Authors: Kim, Soo Kyoung, Kim, Bo Ra, Kim, Kyongyoung, Kim, Sungsu, Jung, Jung Hwa, Hahm, Jong Ryeal, Jung, Jaehoon
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2015
• Subjects: acromegaly; Acromegaly - complications; Acromegaly - diagnosis; Acromegaly - surgery; Adrenalectomy; Blood Glucose - metabolism; Cushing Syndrome - complications; Cushing Syndrome - diagnosis; Cushing Syndrome - surgery; Cushing's syndrome; diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - surgery; Dose-Response Relationship, Drug; Female; Glycated Hemoglobin A - metabolism; Humans; Hydrocortisone; Hypoglycemic Agents - administration & dosage; Incidental Findings; Insulin - administration & dosage; Magnetic Resonance Imaging; Middle Aged; Remission Induction
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.54.3302

Endocrine diseases are frequently accompanied by diabetes mellitus and treatment of an underlying endocrine disease often improves glucose control. The co-occurrence of acromegaly and Cushing's syndrome is extremely rare. We herein describe a patient who showed a dramatic improvement in glucose control following treatment for co-existing acromegaly and Cushing's syndrome. An adrenal mass was incidentally discovered during a routine evaluation of a 56-year-old woman who was subsequently diagnosed with acromegaly and a unilateral cortisol-producing adrenal adenoma. Her blood glucose was poorly controlled despite receiving high-dose insulin therapy. After undergoing adrenalectomy for Cushing's syndrome, her insulin dosage was decreased by almost 50%. The insulin treatment was discontinued following the treatment of acromegaly.