Time to surgery and survival in breast cancer

• Published in: BMC surgery Vol. 22; no. 1; pp. 1 - 8
• Main Authors: An, Doyeon, Choi, Jihye, Lee, Jaebin, Kim, Jong-Yeup, Kwon, Seonguk, Kim, Jungeun, Lee, Seunghee, Jeon, Seongwoo, Lee, Chungchun, Lee, Suehyun, Woo, Hyekyung
• Format: Journal Article
• Language: English
• Published: London BioMed Central 11.11.2022; BioMed Central Ltd; BMC
• Subjects: Adjuvant treatment; Alcohol; Analysis; Big Data; Breast cancer; Cancer; Cancer patients; Cancer therapies; Chemotherapy; Delayed treatment; Development and progression; Diagnosis; Endocrine therapy; Health aspects; Internal Medicine; Mammography; Mastectomy; Medical prognosis; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Mortality; Multivariate analysis; Neoadjuvant chemotherapy; Patient satisfaction; Patients; Prognosis; Radiation therapy; Registration; Regression analysis; Surgery; Survival; Survival analysis; Time; Neoadjuvant chemotherapy; Breast cancer; Time; Delayed treatment; Surgery
• ISSN: 1471-2482; 1471-2482
• DOI: 10.1186/s12893-022-01835-1

Background This study aimed to investigate the effect of the time from diagnosis to breast cancer surgery on breast cancer patients’ prognosis. Methods Of the 1900 patients diagnosed with invasive (stage 1–3) breast cancer who underwent surgery in KUH between 2012 and 2019, 279 patients were enrolled in this study. All patients, including those who received neoadjuvant chemotherapy, were classified as Model 1 subjects, and those who received immediate surgical treatment were classified as Model 2 subjects. We conducted a Cox regression analysis to identify prognostic factors of breast cancer associated with the time from diagnosis to surgery. Results The univariate results indicated a sharp drop in both groups’ survival rates when the time to surgery was delayed for more than 8 weeks (Model 1 p  = 0.000; Model 2 p  = 0.001). In the multivariate analysis, the hazard ratio (HR) of Model 1increased (HR = 6.84, 95% CI 1.06–44.25) in response to a delay in surgery of more than 8 weeks. Smoking and the American Joint Committee on Cancer (AJCC) staging system had a negative effect on breast cancer prognosis, while hormone therapy had a positive effect. Conclusion For all patients, a delay in breast cancer surgery of more than 8 weeks was inversely associated with survival.