Articular cartilage delamination at eight years following cellular-based repair procedures: a case reports

This report describes two cases of late cartilage delamination in two young adults after two different autologous cell-based techniques for cartilage restoration: 1. Matrix-assisted autologous chondrocyte implantation (MACI) and 2. Hyaluronic acid-bone marrow aspirate concentrate (HA-BMAC). Both cas...

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Bibliographic Details
Published inJournal of experimental orthopaedics Vol. 9; no. 1; p. 90
Main Authors Gobbi, Alberto, Lane, John G., Morales, Macarena, D’Ambrosi, Riccardo
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 07.09.2022
Springer Nature B.V
Wiley
Subjects
Asymptomatic
Biopsy
Body mass index
Bone marrow
Cartilage
Case Report
Case reports
Defects
Hyaluronic acid
Knee
Medicine
Medicine & Public Health
Orthopedics
Surgery
Surgical Orthopedics
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Summary:This report describes two cases of late cartilage delamination in two young adults after two different autologous cell-based techniques for cartilage restoration: 1. Matrix-assisted autologous chondrocyte implantation (MACI) and 2. Hyaluronic acid-bone marrow aspirate concentrate (HA-BMAC). Both cases demonstrate that even in patients who do not present with any ongoing symptoms after primary surgery, a cellular-based graft’s subsequent delamination can occur later. It is possible that regardless of the technique used or the time passed since the surgery, a graft failure may occur at some level, causing delamination of a previously asymptomatic cartilage restoration graft and a traumatic event with long-term follow-up. Surgeons must be alert to this injury and describe histologic findings to determine where failure occurs.
Bibliography:ObjectType-Article-1
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ISSN:2197-1153
2197-1153
DOI:10.1186/s40634-022-00527-2