Mass Spectrometry for Cellular and Tissue Analyses in a Very Small Region

The analysis of biological specimens is now expected to shift from multi-cell analysis to single cells to know about the molecular and cellular behavior precisely. Mass spectrometric approaches to clarify molecular profiles in a cell or very small region have been developed. Such techniques include...

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Bibliographic Details
Published inAnalytical Sciences Vol. 27; no. 2; p. 163
Main Authors TSUYAMA, Naohiro, MIZUNO, Hajime, MASUJIMA, Tsutomu
Format Journal Article
LanguageEnglish
Published Singapore The Japan Society for Analytical Chemistry 2011
Springer Nature Singapore
Japan Science and Technology Agency
Subjects
Analytical Chemistry
Animals
Cell Survival
Cells - cytology
Cells - metabolism
Chemistry
Humans
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Molecular Imaging
Nanotechnology
Organ Specificity
Reviews
Single-Cell Analysis
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Summary:The analysis of biological specimens is now expected to shift from multi-cell analysis to single cells to know about the molecular and cellular behavior precisely. Mass spectrometric approaches to clarify molecular profiles in a cell or very small region have been developed. Such techniques include matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS), secondary-ion mass spectrometry (SIMS), single-cell MALDI and live single-cell mass spectrometry. In this paper, these methods are reviewed, and their characteristics are discussed concerning how these methods achieve our aim.
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ISSN:0910-6340
1348-2246
1348-2246
DOI:10.2116/analsci.27.163