Elucidating the Metabolic Regulation of Liver Regeneration

The regenerative capability of liver is well known, and the mechanisms that regulate liver regeneration are extensively studied. Such analyses have defined general principles that govern the hepatic regenerative response and implicated specific extracellular and intracellular signals as regulated du...

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Bibliographic Details
Published inThe American journal of pathology Vol. 184; no. 2; pp. 309 - 321
Main Authors Huang, Jiansheng, Rudnick, David A
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2014
American Society for Investigative Pathology
Subjects
Animals
Epigenesis, Genetic - drug effects
Glucose - pharmacology
Hepatocytes - cytology
Hepatocytes - drug effects
Hepatocytes - metabolism
Humans
Liver - drug effects
Liver - metabolism
Liver - surgery
Liver Regeneration - drug effects
Pathology
Review
Xenobiotics - pharmacology
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Summary:The regenerative capability of liver is well known, and the mechanisms that regulate liver regeneration are extensively studied. Such analyses have defined general principles that govern the hepatic regenerative response and implicated specific extracellular and intracellular signals as regulated during and essential for normal liver regeneration. Nevertheless, the most proximal events that stimulate liver regeneration and the distal signals that terminate this process remain incompletely understood. Recent data suggest that the metabolic response to hepatic insufficiency might be the proximal signal that initiates regenerative hepatocellular proliferation. This review provides an overview of the data in support of a metabolic model of liver regeneration and reflects on the clinical implications and areas for further study suggested by these findings.
ISSN:0002-9440
1525-2191
DOI:10.1016/j.ajpath.2013.04.034