Impact of Rosuvastatin on Contrast-Induced Acute Kidney Injury in Patients at High Risk for Nephropathy Undergoing Elective Angiography

• Published in: The American journal of cardiology Vol. 115; no. 7; pp. 867 - 871
• Main Authors: Abaci, Okay, MD, Arat Ozkan, Alev, MD, Kocas, Cuneyt, MD, Cetinkal, Gokhan, MD, Sukru Karaca, Osman, MD, Baydar, Onur, MD, Kaya, Aysem, PhD, Gurmen, Tevfik, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015; Elsevier Limited
• Subjects: Acute Coronary Syndrome - diagnostic imaging; Acute Coronary Syndrome - drug therapy; Acute coronary syndromes; Acute Kidney Injury - chemically induced; Acute Kidney Injury - physiopathology; Acute Kidney Injury - prevention & control; Age; Aged; Cardiology; Cardiovascular; Cardiovascular disease; Confidence intervals; Consent; Contrast agents; Contrast Media - adverse effects; Coronary Angiography - adverse effects; Coronary Angiography - methods; Coronary vessels; Diabetes; Diuretics; Drug therapy; Female; Fluorobenzenes - therapeutic use; Follow-Up Studies; Glomerular Filtration Rate - drug effects; Heart attacks; Heart failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Male; Medical imaging; Mortality; Prognosis; Pyrimidines - therapeutic use; Retrospective Studies; Risk Factors; Rosuvastatin Calcium; Statins; Sulfonamides - therapeutic use; Variables
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2015.01.007

Although statins have been shown to prevent contrast-induced acute kidney injury in patients with acute coronary syndromes, the benefit of statins is not known for patients at high risk for nephropathy who undergo elective coronary angiography. Two hundred twenty consecutive statin-naive patients with chronic kidney disease (estimated glomerular filtration rate <60 ml/min/1.73 m2 ) who underwent elective coronary or peripheral angiography were randomly assigned to receive rosuvastatin (40 mg on admission, followed by 20 mg/day; n = 110) or no statin treatment (control group, n = 110). Contrast-induced acute kidney injury was defined by an absolute increase in serum creatinine of ≥0.5 mg/dl or a relative increase of ≥25% measured 48 or 72 hours after the procedure. Contrast-induced acute kidney injury occurred in 15 patients (7.2%), 9 (8.5%) in the control group and 6 (5.8%) in the rosuvastatin group (p = 0.44). The incidences of adverse cardiovascular and renal events (death, dialysis, myocardial infarction, stroke, or persistent renal damage) were similar between the two groups at follow-up. In conclusion, rosuvastatin did not reduce the risk for contrast-induced acute kidney injury or other clinically relevant outcomes in at-risk patients who underwent coronary and peripheral vascular angiography.