16S rRNA methylase-producing, gram-negative pathogens, Japan

• Published in: Emerging infectious diseases Vol. 13; no. 4; pp. 642 - 646
• Main Authors: Yamane, Kunikazu, Wachino, Jun-ichi, Suzuki, Satowa, Shibata, Naohiro, Kato, Haru, Shibayama, Keigo, Kimura, Kouji, Kai, Kumiko, Ishikawa, Satoshi, Ozawa, Yoshiyuki, Konda, Toshifumi, Arakawa, Yoshichika
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.04.2007; Centers for Disease Control and Prevention
• Subjects: 16S rRNA methylase; Aminoglycoside resistance; Aminoglycosides - pharmacology; Anti-Bacterial Agents - pharmacology; Diagnosis; Dibekacin - analogs & derivatives; Dibekacin - pharmacology; Dispatch; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Female; Genetic aspects; gram-negative bacteria; Gram-Negative Bacteria - drug effects; Gram-Negative Bacteria - enzymology; Gram-Negative Bacteria - genetics; Gram-Negative Bacteria - isolation & purification; Gram-negative bacterial infections; Gram-Negative Bacterial Infections - microbiology; Humans; Japan; Methyltransferases; Methyltransferases - genetics; Microbial Sensitivity Tests; Prevention; Ribosomal RNA; RNA, Ribosomal, 16S - genetics; Japan
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid1304.060501

To investigate the exact isolation frequency of 16S rRNA methylase-producing, gram-negative pathogenic bacteria, we tested 87,626 clinical isolates from 169 hospitals. Twenty-six strains from 16 hospitals harbored 16S rRNA methylase genes, which suggests sparse but diffuse spread of pan-aminoglycoside-resistant microbes in Japan.