Effect of Transcutaneous Aortic Valve Implantation on the Heyde's Syndrome

• Published in: The American journal of cardiology Vol. 114; no. 6; pp. 953 - 954
• Main Authors: Benton, Stewart Michael, MD, Kumar, Anupam, MD, Crenshaw, Marshall, MD, Fredi, Joseph L., MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2014; Elsevier Limited
• Subjects: Aged; Antigens; Aortic Valve Stenosis - complications; Aortic Valve Stenosis - diagnostic imaging; Aortic Valve Stenosis - surgery; Cardiac arrhythmia; Cardiology; Cardiovascular; Disclosure; Echocardiography; Follow-Up Studies; Gastrointestinal Hemorrhage - complications; Heart Valve Prosthesis Implantation - methods; Hemostasis - physiology; Humans; Male; Molecular weight; Patients; Recovery of Function; Syndrome; von Willebrand Disease, Type 2 - blood; von Willebrand Disease, Type 2 - etiology; von Willebrand Factor - metabolism
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2014.06.025

The association between aortic valve stenosis and gastrointestinal bleeding, traditionally known as Heyde's syndrome, is the result of a quantitative loss of the highest molecular weight von Willebrand multimers (type 2A von Willebrand syndrome). This results in bleeding from areas of high shear stress such as gastrointestinal angiodysplasias. Correction of this bleeding diathesis after surgical aortic valve replacement has been well described. The effect of transcutaneous aortic valve implantation on Heyde's syndrome has yet to be studied. Herein, we report a patient with severe aortic stenosis, type 2A von Willebrand syndrome, and hemorrhagic shock from gastrointestinal bleeding who underwent successful transcutaneous aortic valve implantation.