Cerium oxide nanoparticles: green synthesis and biological applications

• Published in: International Journal of Nanomedicine Vol. 12; pp. 1401 - 1413
• Main Authors: Charbgoo, Fahimeh, Ahmad, Mansor Bin, Darroudi, Majid
• Format: Journal Article Book Review
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2017; Taylor & Francis Ltd; Dove Medical Press
• Subjects: biocompatibility; biological application; Biomedical materials; Biopolymers - chemistry; Biosensing Techniques; Biosynthesis; Cerium; Cerium - chemistry; Cerium - toxicity; Cerium oxide nanoparticles; Cerium oxides; Chemistry; Cytotoxicity; Defects; Enzymes - metabolism; Green chemistry; Green Chemistry Technology - methods; green synthesis; Health aspects; Hydrogen peroxide; Innovations; Metal oxides; Methods; nanobiotechnology; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - toxicity; Nanotechnology; Oxidation; Oxidative stress; Review; Iran; New York; Malaysia; cerium oxide nanoparticles; morphology; size; green synthesis; biocompatibility; surface Ce3
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S124855

CeO nanoparticles (NPs) have shown promising approaches as therapeutic agents in biology and medical sciences. The physicochemical properties of CeO -NPs, such as size, agglomeration status in liquid, and surface charge, play important roles in the ultimate interactions of the NP with target cells. Recently, CeO -NPs have been synthesized through several bio-directed methods applying natural and organic matrices as stabilizing agents in order to prepare biocompatible CeO -NPs, thereby solving the challenges regarding safety, and providing the appropriate situation for their effective use in biomedicine. This review discusses the different green strategies for CeO -NPs synthesis, their advantages and challenges that are to be overcome. In addition, this review focuses on recent progress in the potential application of CeO -NPs in biological and medical fields. Exploiting biocompatible CeO -NPs may improve outcomes profoundly with the promise of effective neurodegenerative therapy and multiple applications in nanobiotechnology.