INHIBIT-Inspired Two-Output DNA Logic Gates Based on Surface-Enhanced Raman Scattering

• Published in: Chemistry : a European journal Vol. 21; no. 41; pp. 14301 - 14304
• Main Authors: Wu, Zitong, Dong, Boran, Zhou, Xiaodong, Shen, Aiguo, Hu, Jiming
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 05.10.2015; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: analytical methods; Base Sequence; Chemistry; Construction; Deoxyribonucleic acid; DNA; DNA - chemistry; Field programmable gate arrays; Gates (circuits); half-adder; Inhibition; Logic circuits; logic gates; Nucleic Acid Conformation; Raman scattering; Reporting; Spectrum Analysis, Raman - methods; Strategy; surface-enhanced Raman scattering; logic gates; half-adder; surface-enhanced Raman scattering; analytical methods; DNA
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201502938

Herein, we presented a novel logic gate based on an INHIBITION gate that performs parallel readouts. Logic gates performing INHIBITION and YES/OR were constructed using surface‐enhanced Raman scattering as optical outputs for the first time. The strategy allowed for simultaneous reading of outputs in one tube. The applicability of this strategy has been successfully exemplified in the construction of half‐adder using the two‐output logic gates as reporting gates. This reporting strategy provides additional design flexibility for dynamic DNA devices. Readout by SERS: With the help of surface‐enhanced Raman scattering, we can construct a logic gate operating two functions simultaneously inspired from INHIBIT logic gate. This strategy enables us to design a modular logic circuit.