Leptin and ghrelin concentrations and weight loss in Parkinson's disease
Fiszer U, Michałowska M, Baranowska B, Wolińska‐Witort E, Jeske W, Jethon M, Piaścik‐Gromada M, Marcinowska‐Suchowierska E. Leptin and ghrelin concentrations and weight loss in Parkinson’s disease. Acta Neurol Scand: 2010: 121: 230–236. © 2009 The Authors Journal compilation © 2009 Blackwell Munksg...
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| Published in | Acta neurologica Scandinavica Vol. 121; no. 4; pp. 230 - 236 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Oxford, UK
Blackwell Publishing Ltd
01.04.2010
Blackwell |
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| Online Access | Get full text |
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| Abstract | Fiszer U, Michałowska M, Baranowska B, Wolińska‐Witort E, Jeske W, Jethon M, Piaścik‐Gromada M, Marcinowska‐Suchowierska E. Leptin and ghrelin concentrations and weight loss in Parkinson’s disease.
Acta Neurol Scand: 2010: 121: 230–236.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.
Objectives – To investigate the role of leptin, ghrelin, GH and IGF‐1 in energy balance disturbances in Parkinson’s disease (PD).
Materials and methods – Thirty‐nine patients were included: 11 PD patients with unintentional weight loss, 16 PD patients without weight loss and 12 controls. UPDRS, MMSE, MADRS, appetite scale, BMI, adipose tissue content, plasma leptin and active ghrelin concentrations and serum GH, IGF‐1, TSH, T3 and T4, concentrations were evaluated.
Results – A lower plasma leptin concentration and a higher serum IGF‐1 concentration were found in PD patients with weight loss. BMI and the content of adipose tissue were positively correlated with leptin concentration in all PD patients. Paradoxically, the lower BMI was, the lower plasma active ghrelin concentration was in PD patients with the weight loss.
Conclusion – These findings confirm that changes of plasma leptin concentration occur in PD patients with loss of weight. |
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| AbstractList | Fiszer U, Michałowska M, Baranowska B, Wolińska‐Witort E, Jeske W, Jethon M, Piaścik‐Gromada M, Marcinowska‐Suchowierska E. Leptin and ghrelin concentrations and weight loss in Parkinson’s disease.
Acta Neurol Scand: 2010: 121: 230–236.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.
Objectives – To investigate the role of leptin, ghrelin, GH and IGF‐1 in energy balance disturbances in Parkinson’s disease (PD).
Materials and methods – Thirty‐nine patients were included: 11 PD patients with unintentional weight loss, 16 PD patients without weight loss and 12 controls. UPDRS, MMSE, MADRS, appetite scale, BMI, adipose tissue content, plasma leptin and active ghrelin concentrations and serum GH, IGF‐1, TSH, T3 and T4, concentrations were evaluated.
Results – A lower plasma leptin concentration and a higher serum IGF‐1 concentration were found in PD patients with weight loss. BMI and the content of adipose tissue were positively correlated with leptin concentration in all PD patients. Paradoxically, the lower BMI was, the lower plasma active ghrelin concentration was in PD patients with the weight loss.
Conclusion – These findings confirm that changes of plasma leptin concentration occur in PD patients with loss of weight. Fiszer U, Michalowska M, Baranowska B, Wolinska-Witort E, Jeske W, Jethon M, Piascik-Gromada M, Marcinowska-Suchowierska E. Leptin and ghrelin concentrations and weight loss in Parkinson's disease. Acta Neurol Scand: 2010: 121: 230-236. [copy ] 2009 The Authors Journal compilation [copy ] 2009 Blackwell Munksgaard.Objectives - To investigate the role of leptin, ghrelin, GH and IGF-1 in energy balance disturbances in Parkinson's disease (PD).Materials and methods - Thirty-nine patients were included: 11 PD patients with unintentional weight loss, 16 PD patients without weight loss and 12 controls. UPDRS, MMSE, MADRS, appetite scale, BMI, adipose tissue content, plasma leptin and active ghrelin concentrations and serum GH, IGF-1, TSH, T3 and T4, concentrations were evaluated.Results - A lower plasma leptin concentration and a higher serum IGF-1 concentration were found in PD patients with weight loss. BMI and the content of adipose tissue were positively correlated with leptin concentration in all PD patients. Paradoxically, the lower BMI was, the lower plasma active ghrelin concentration was in PD patients with the weight loss.Conclusion - These findings confirm that changes of plasma leptin concentration occur in PD patients with loss of weight. OBJECTIVESTo investigate the role of leptin, ghrelin, GH and IGF-1 in energy balance disturbances in Parkinson's disease (PD).MATERIALS AND METHODSThirty-nine patients were included: 11 PD patients with unintentional weight loss, 16 PD patients without weight loss and 12 controls. UPDRS, MMSE, MADRS, appetite scale, BMI, adipose tissue content, plasma leptin and active ghrelin concentrations and serum GH, IGF-1, TSH, T3 and T4, concentrations were evaluated.RESULTSA lower plasma leptin concentration and a higher serum IGF-1 concentration were found in PD patients with weight loss. BMI and the content of adipose tissue were positively correlated with leptin concentration in all PD patients. Paradoxically, the lower BMI was, the lower plasma active ghrelin concentration was in PD patients with the weight loss.CONCLUSIONThese findings confirm that changes of plasma leptin concentration occur in PD patients with loss of weight. To investigate the role of leptin, ghrelin, GH and IGF-1 in energy balance disturbances in Parkinson's disease (PD). Thirty-nine patients were included: 11 PD patients with unintentional weight loss, 16 PD patients without weight loss and 12 controls. UPDRS, MMSE, MADRS, appetite scale, BMI, adipose tissue content, plasma leptin and active ghrelin concentrations and serum GH, IGF-1, TSH, T3 and T4, concentrations were evaluated. A lower plasma leptin concentration and a higher serum IGF-1 concentration were found in PD patients with weight loss. BMI and the content of adipose tissue were positively correlated with leptin concentration in all PD patients. Paradoxically, the lower BMI was, the lower plasma active ghrelin concentration was in PD patients with the weight loss. These findings confirm that changes of plasma leptin concentration occur in PD patients with loss of weight. |
| Author | Jethon, M. Jeske, W. Marcinowska-Suchowierska, E. Baranowska, B. Wolińska-Witort, E. Piaścik-Gromada, M. Fiszer, U. Michałowska, M. |
| Author_xml | – sequence: 1 givenname: U. surname: Fiszer fullname: Fiszer, U. organization: Department of Neurology and Epileptology, Medical Center for Postgraduate Education, Warsaw, Poland – sequence: 2 givenname: M. surname: Michałowska fullname: Michałowska, M. organization: Department of Neurology and Epileptology, Medical Center for Postgraduate Education, Warsaw, Poland – sequence: 3 givenname: B. surname: Baranowska fullname: Baranowska, B. organization: Department of Neuroendocrinology, Medical Center for Postgraduate Education, Warsaw, Poland – sequence: 4 givenname: E. surname: Wolińska-Witort fullname: Wolińska-Witort, E. organization: Department of Neuroendocrinology, Medical Center for Postgraduate Education, Warsaw, Poland – sequence: 5 givenname: W. surname: Jeske fullname: Jeske, W. organization: Department of Endocrinology, Medical Center for Postgraduate Education, Warsaw, Poland – sequence: 6 givenname: M. surname: Jethon fullname: Jethon, M. organization: Department of Neurology and Epileptology, Medical Center for Postgraduate Education, Warsaw, Poland – sequence: 7 givenname: M. surname: Piaścik-Gromada fullname: Piaścik-Gromada, M. organization: Department of Neurology and Epileptology, Medical Center for Postgraduate Education, Warsaw, Poland – sequence: 8 givenname: E. surname: Marcinowska-Suchowierska fullname: Marcinowska-Suchowierska, E. organization: Department of Family and Internal Medicine, Medical Center for Postgraduate Education, Warsaw, Poland |
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| Keywords | Nervous system diseases ghrelin Parkinson's disease Leptin Central nervous system disease Parkinson disease weight loss Degenerative disease Weight Cerebral disorder Extrapyramidal syndrome |
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| Snippet | Fiszer U, Michałowska M, Baranowska B, Wolińska‐Witort E, Jeske W, Jethon M, Piaścik‐Gromada M, Marcinowska‐Suchowierska E. Leptin and ghrelin concentrations... To investigate the role of leptin, ghrelin, GH and IGF-1 in energy balance disturbances in Parkinson's disease (PD). Thirty-nine patients were included: 11 PD... OBJECTIVESTo investigate the role of leptin, ghrelin, GH and IGF-1 in energy balance disturbances in Parkinson's disease (PD).MATERIALS AND METHODSThirty-nine... Fiszer U, Michalowska M, Baranowska B, Wolinska-Witort E, Jeske W, Jethon M, Piascik-Gromada M, Marcinowska-Suchowierska E. Leptin and ghrelin concentrations... |
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| SubjectTerms | Adipose Tissue - metabolism Aged Appetite - physiology Biological and medical sciences Body Mass Index Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Energy Metabolism - physiology Female ghrelin Ghrelin - blood Growth Hormone - metabolism Humans Insulin-Like Growth Factor I - metabolism leptin Leptin - blood Male Medical sciences Middle Aged Neurology Parkinson Disease - metabolism Parkinson Disease - physiopathology Parkinson's disease Thyroid Hormones - metabolism Thyrotropin - metabolism Weight Loss |
| Title | Leptin and ghrelin concentrations and weight loss in Parkinson's disease |
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