Leptin and ghrelin concentrations and weight loss in Parkinson's disease

• Published in: Acta neurologica Scandinavica Vol. 121; no. 4; pp. 230 - 236
• Main Authors: Fiszer, U., Michałowska, M., Baranowska, B., Wolińska-Witort, E., Jeske, W., Jethon, M., Piaścik-Gromada, M., Marcinowska-Suchowierska, E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2010; Blackwell
• Subjects: Adipose Tissue - metabolism; Aged; Appetite - physiology; Biological and medical sciences; Body Mass Index; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Energy Metabolism - physiology; Female; ghrelin; Ghrelin - blood; Growth Hormone - metabolism; Humans; Insulin-Like Growth Factor I - metabolism; leptin; Leptin - blood; Male; Medical sciences; Middle Aged; Neurology; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Parkinson's disease; Thyroid Hormones - metabolism; Thyrotropin - metabolism; Weight Loss; Nervous system diseases; ghrelin; Parkinson's disease; Leptin; Central nervous system disease; Parkinson disease; weight loss; Degenerative disease; Weight; Cerebral disorder; Extrapyramidal syndrome
• ISSN: 0001-6314; 1600-0404
• DOI: 10.1111/j.1600-0404.2009.01185.x

Fiszer U, Michałowska M, Baranowska B, Wolińska‐Witort E, Jeske W, Jethon M, Piaścik‐Gromada M, Marcinowska‐Suchowierska E. Leptin and ghrelin concentrations and weight loss in Parkinson’s disease. 
Acta Neurol Scand: 2010: 121: 230–236.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objectives –  To investigate the role of leptin, ghrelin, GH and IGF‐1 in energy balance disturbances in Parkinson’s disease (PD). Materials and methods –  Thirty‐nine patients were included: 11 PD patients with unintentional weight loss, 16 PD patients without weight loss and 12 controls. UPDRS, MMSE, MADRS, appetite scale, BMI, adipose tissue content, plasma leptin and active ghrelin concentrations and serum GH, IGF‐1, TSH, T3 and T4, concentrations were evaluated. Results –  A lower plasma leptin concentration and a higher serum IGF‐1 concentration were found in PD patients with weight loss. BMI and the content of adipose tissue were positively correlated with leptin concentration in all PD patients. Paradoxically, the lower BMI was, the lower plasma active ghrelin concentration was in PD patients with the weight loss. Conclusion –  These findings confirm that changes of plasma leptin concentration occur in PD patients with loss of weight.