Circulating Cytokines and Alarmins Associated with Placental Inflammation in High-Risk Pregnancies

Problem Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment. Method of study The inflammatory profile of villous tissue was studied in pregnancies at high‐risk of placental dysfunct...

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Published inAmerican journal of reproductive immunology (1989) Vol. 72; no. 4; pp. 422 - 434
Main Authors Girard, Sylvie, Heazell, Alexander E. P., Derricott, Hayley, Allan, Stuart M., Sibley, Colin P., Abrahams, Vikki M., Jones, Rebecca L.
Format Journal Article
LanguageEnglish
Published Denmark Blackwell Publishing Ltd 01.10.2014
Wiley Subscription Services, Inc
BlackWell Publishing Ltd
Subjects
Adolescent
Adult
Biomarkers - blood
Clinical Aspects of Reproductive Immunology
Cytokines - blood
Female
Fetuses
High-risk pregnancy
HMGB1 Protein - blood
Humans
Inflammation
Inflammation - blood
Interleukin 1 Receptor Antagonist Protein - blood
Interleukin-10 - blood
Interleukin-18 - blood
Interleukin-1alpha - blood
Interleukin-1beta - blood
Macrophages - immunology
Placenta - immunology
Placenta - physiopathology
placental dysfunction
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - physiopathology
Pregnancy, High-Risk - blood
Prenatal development
stillbirth
Young Adult
placental dysfunction
stillbirth
High-risk pregnancy
inflammation
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Summary:Problem Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment. Method of study The inflammatory profile of villous tissue was studied in pregnancies at high‐risk of placental dysfunction and compared to uncomplicated pregnancies. The systemic inflammatory profile was assessed in matched maternal serum samples in cases of reduced fetal movements (RFM). Results Placentas from RFM pregnancies had a unique inflammatory profile characterized by increased interleukin (IL)‐1 receptor antagonist and decreased IL‐10 expression, concomitant with increased numbers of placental macrophages. This aberrant cytokine profile was evident in maternal serum in RFM, as were increased levels of alarmins (uric acid, HMGB1, cell‐free fetal DNA). Conclusion This distinct inflammatory profile at the maternal‐fetal interface, mirrored in maternal serum, could represent biomarkers of placental inflammation and could offer novel therapeutic options to protect the placenta and fetus from an adverse maternal environment.
Bibliography:ArticleID:AJI12274
Canadian Institute for Health Research Fellowship (SG)
Manchester Biomedical Research Centre
NIHR Greater Manchester Clinical Local Research Network
NIHR Manchester Wellcome Trust Clinical Research Facility
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Figure S1. Levels of IL-1α, TNF-α and in high-risk pregnancies. Protein levels of IL-1α (A), TNF-α (B), and IL-6 (C), were unchanged in placentas from high-risk pregnancies associated with RFM, FGR or PE as compared with normal term control placenta. Results presented as median.Figure S2. mRNA levels of inflammatory mediators in placentas from pregnancies with RFM. mRNA levels of IL-1R2 (A), NLRP3 (B), and caspase-1 (C) were unchanged in placenta from high-risk pregnancies associated with RFM as compared to normal term tissue. Results presented as median.
The copyright line for this article was changed on 29th April 2016 after original online publication.
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Citation Girard S, Heazell AEP, Derricott H, Allan SM, Sibley CP, Abrahams VM, Jones RL. Circulating cytokines and alarmins associated with placental inflammation in high-risk pregnancies. Am J Reprod Immunol 2014; 72:422–434
Present address: Department of Obstetrics and Gynecology, Universite de Montreal, Sainte-Justine Hospital Research Centre, Montreal, QC, Canada
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12274