Exploiting the Freshwater Shrimp Neocaridina denticulata as Aquatic Invertebrate Model to Evaluate Nontargeted Pesticide Induced Toxicity by Investigating Physiologic and Biochemical Parameters

As a nicotinoid neurotoxic insecticide, imidacloprid (IMI) works by disrupting nerve transmission via nicotinic acetylcholine receptor (nAChR). Although IMI is specifically targeting insects, nontarget animals such as the freshwater shrimp, Neocaridina denticulata, could also be affected, thus causi...

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Published inAntioxidants Vol. 10; no. 3; p. 391
Main Authors Siregar, Petrus, Suryanto, Michael Edbert, Chen, Kelvin H.-C., Huang, Jong-Chin, Chen, Hong-Ming, Kurnia, Kevin Adi, Santoso, Fiorency, Hussain, Akhlaq, Ngoc Hieu, Bui Thi, Saputra, Ferry, Audira, Gilbert, Roldan, Marri Jmelou M., Fernandez, Rey Arturo, Macabeo, Allan Patrick G., Lai, Hong-Thih, Hsiao, Chung-Der
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 05.03.2021
MDPI
Subjects
acetylcholine
Acetylcholine receptors (nicotinic)
Aquatic environment
cardiac activity
Energy metabolism
Experiments
Freshwater resources
Heart
heart rate
Imidacloprid
Immobilization
insecticide
Insecticides
Insects
Invertebrates
Locomotion
locomotion activity
Locomotor activity
Neocaridina denticulata
nerve tissue
Nervous system
Neurotoxicity
Neurotransmission
nicotinic receptors
Nontarget organisms
Oxidative metabolism
Oxidative stress
Pesticides
shrimp
Ventilation
Taiwan
Neocaridina denticulata
shrimp
cardiac activity
insecticide
locomotion activity
ecotoxicity
imidacloprid
Online AccessGet full text
ISSN2076-3921
2076-3921
DOI10.3390/antiox10030391

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Abstract As a nicotinoid neurotoxic insecticide, imidacloprid (IMI) works by disrupting nerve transmission via nicotinic acetylcholine receptor (nAChR). Although IMI is specifically targeting insects, nontarget animals such as the freshwater shrimp, Neocaridina denticulata, could also be affected, thus causing adverse effects on the aquatic environment. To investigate IMI toxicity on nontarget organisms like N. denticulata, their physiology (locomotor activity, heartbeat, and gill ventilation) and biochemical factors (oxidative stress, energy metabolism) after IMI exposure were examined. IMI exposure at various concentrations (0.03125, 0.0625, 0.125, 0.25, 0.5, and 1 ppm) to shrimp after 24, 48, 72 h led to dramatic reduction of locomotor activity even at low concentrations. Meanwhile, IMI exposure after 92 h caused reduced heartbeat and gill ventilation at high concentrations. Biochemical assays were performed to investigate oxidative stress and energy metabolism. Interestingly, locomotion immobilization and cardiac activity were rescued after acetylcholine administration. Through molecular docking, IMI demonstrated high binding affinity to nAChR. Thus, locomotor activity and heartbeat in shrimp after IMI exposure may be caused by nAChR blockade and not alterations caused by oxidative stress and energy metabolism. To summarize, N. denticulata serves as an excellent and sensitive aquatic invertebrate model to conduct pesticide toxicity assays that encompass physiologic and biochemical examinations.
AbstractList As a nicotinoid neurotoxic insecticide, imidacloprid (IMI) works by disrupting nerve transmission via nicotinic acetylcholine receptor (nAChR). Although IMI is specifically targeting insects, nontarget animals such as the freshwater shrimp, Neocaridina denticulata, could also be affected, thus causing adverse effects on the aquatic environment. To investigate IMI toxicity on nontarget organisms like N. denticulata, their physiology (locomotor activity, heartbeat, and gill ventilation) and biochemical factors (oxidative stress, energy metabolism) after IMI exposure were examined. IMI exposure at various concentrations (0.03125, 0.0625, 0.125, 0.25, 0.5, and 1 ppm) to shrimp after 24, 48, 72 h led to dramatic reduction of locomotor activity even at low concentrations. Meanwhile, IMI exposure after 92 h caused reduced heartbeat and gill ventilation at high concentrations. Biochemical assays were performed to investigate oxidative stress and energy metabolism. Interestingly, locomotion immobilization and cardiac activity were rescued after acetylcholine administration. Through molecular docking, IMI demonstrated high binding affinity to nAChR. Thus, locomotor activity and heartbeat in shrimp after IMI exposure may be caused by nAChR blockade and not alterations caused by oxidative stress and energy metabolism. To summarize, N. denticulata serves as an excellent and sensitive aquatic invertebrate model to conduct pesticide toxicity assays that encompass physiologic and biochemical examinations.
As a nicotinoid neurotoxic insecticide, imidacloprid (IMI) works by disrupting nerve transmission via nicotinic acetylcholine receptor (nAChR). Although IMI is specifically targeting insects, nontarget animals such as the freshwater shrimp, Neocaridina denticulata, could also be affected, thus causing adverse effects on the aquatic environment. To investigate IMI toxicity on nontarget organisms like N. denticulata, their physiology (locomotor activity, heartbeat, and gill ventilation) and biochemical factors (oxidative stress, energy metabolism) after IMI exposure were examined. IMI exposure at various concentrations (0.03125, 0.0625, 0.125, 0.25, 0.5, and 1 ppm) to shrimp after 24, 48, 72 h led to dramatic reduction of locomotor activity even at low concentrations. Meanwhile, IMI exposure after 92 h caused reduced heartbeat and gill ventilation at high concentrations. Biochemical assays were performed to investigate oxidative stress and energy metabolism. Interestingly, locomotion immobilization and cardiac activity were rescued after acetylcholine administration. Through molecular docking, IMI demonstrated high binding affinity to nAChR. Thus, locomotor activity and heartbeat in shrimp after IMI exposure may be caused by nAChR blockade and not alterations caused by oxidative stress and energy metabolism. To summarize, N. denticulata serves as an excellent and sensitive aquatic invertebrate model to conduct pesticide toxicity assays that encompass physiologic and biochemical examinations.As a nicotinoid neurotoxic insecticide, imidacloprid (IMI) works by disrupting nerve transmission via nicotinic acetylcholine receptor (nAChR). Although IMI is specifically targeting insects, nontarget animals such as the freshwater shrimp, Neocaridina denticulata, could also be affected, thus causing adverse effects on the aquatic environment. To investigate IMI toxicity on nontarget organisms like N. denticulata, their physiology (locomotor activity, heartbeat, and gill ventilation) and biochemical factors (oxidative stress, energy metabolism) after IMI exposure were examined. IMI exposure at various concentrations (0.03125, 0.0625, 0.125, 0.25, 0.5, and 1 ppm) to shrimp after 24, 48, 72 h led to dramatic reduction of locomotor activity even at low concentrations. Meanwhile, IMI exposure after 92 h caused reduced heartbeat and gill ventilation at high concentrations. Biochemical assays were performed to investigate oxidative stress and energy metabolism. Interestingly, locomotion immobilization and cardiac activity were rescued after acetylcholine administration. Through molecular docking, IMI demonstrated high binding affinity to nAChR. Thus, locomotor activity and heartbeat in shrimp after IMI exposure may be caused by nAChR blockade and not alterations caused by oxidative stress and energy metabolism. To summarize, N. denticulata serves as an excellent and sensitive aquatic invertebrate model to conduct pesticide toxicity assays that encompass physiologic and biochemical examinations.
As a nicotinoid neurotoxic insecticide, imidacloprid (IMI) works by disrupting nerve transmission via nicotinic acetylcholine receptor (nAChR). Although IMI is specifically targeting insects, nontarget animals such as the freshwater shrimp, Neocaridina denticulata , could also be affected, thus causing adverse effects on the aquatic environment. To investigate IMI toxicity on nontarget organisms like N. denticulata , their physiology (locomotor activity, heartbeat, and gill ventilation) and biochemical factors (oxidative stress, energy metabolism) after IMI exposure were examined. IMI exposure at various concentrations (0.03125, 0.0625, 0.125, 0.25, 0.5, and 1 ppm) to shrimp after 24, 48, 72 h led to dramatic reduction of locomotor activity even at low concentrations. Meanwhile, IMI exposure after 92 h caused reduced heartbeat and gill ventilation at high concentrations. Biochemical assays were performed to investigate oxidative stress and energy metabolism. Interestingly, locomotion immobilization and cardiac activity were rescued after acetylcholine administration. Through molecular docking, IMI demonstrated high binding affinity to nAChR. Thus, locomotor activity and heartbeat in shrimp after IMI exposure may be caused by nAChR blockade and not alterations caused by oxidative stress and energy metabolism. To summarize, N. denticulata serves as an excellent and sensitive aquatic invertebrate model to conduct pesticide toxicity assays that encompass physiologic and biochemical examinations.
As a nicotinoid neurotoxic insecticide, imidacloprid (IMI) works by disrupting nerve transmission via nicotinic acetylcholine receptor (nAChR). Although IMI is specifically targeting insects, nontarget animals such as the freshwater shrimp, , could also be affected, thus causing adverse effects on the aquatic environment. To investigate IMI toxicity on nontarget organisms like , their physiology (locomotor activity, heartbeat, and gill ventilation) and biochemical factors (oxidative stress, energy metabolism) after IMI exposure were examined. IMI exposure at various concentrations (0.03125, 0.0625, 0.125, 0.25, 0.5, and 1 ppm) to shrimp after 24, 48, 72 h led to dramatic reduction of locomotor activity even at low concentrations. Meanwhile, IMI exposure after 92 h caused reduced heartbeat and gill ventilation at high concentrations. Biochemical assays were performed to investigate oxidative stress and energy metabolism. Interestingly, locomotion immobilization and cardiac activity were rescued after acetylcholine administration. Through molecular docking, IMI demonstrated high binding affinity to nAChR. Thus, locomotor activity and heartbeat in shrimp after IMI exposure may be caused by nAChR blockade and not alterations caused by oxidative stress and energy metabolism. To summarize, serves as an excellent and sensitive aquatic invertebrate model to conduct pesticide toxicity assays that encompass physiologic and biochemical examinations.
Author Fernandez, Rey Arturo
Santoso, Fiorency
Saputra, Ferry
Suryanto, Michael Edbert
Hsiao, Chung-Der
Macabeo, Allan Patrick G.
Audira, Gilbert
Roldan, Marri Jmelou M.
Hussain, Akhlaq
Ngoc Hieu, Bui Thi
Kurnia, Kevin Adi
Lai, Hong-Thih
Siregar, Petrus
Huang, Jong-Chin
Chen, Hong-Ming
Chen, Kelvin H.-C.
AuthorAffiliation 7 Center for Nanotechnology, Chung Yuan Christian University, Chung-Li 320314, Taiwan
1 Department of Chemistry, Chung Yuan Christian University, Chung-Li 320314, Taiwan; g10765013@cycu.edu.tw (P.S.); hieubtn90@gmail.com (B.T.N.H.); g10701304@cycu.edu.tw (G.A.)
5 Faculty of Pharmacy and The Graduate School, University of Santo Tomas, Manila 1008, Philippines; mmroldan@ust.edu.ph
6 Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila 1008, Philippines; reyarturo.tapia.fernandez@gmail.com
4 Department of Aquatic Biosciences, National Chiayi University, 300 University Rd., Chiayi 60004, Taiwan; wwwtt333@gmail.com
2 Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan; g10865014@cycu.edu.tw (M.E.S.); g10865016@cycu.edu.tw (K.A.K.); g10766011@cycu.edu.tw (F.S.); g10765017@cycu.edu.tw (A.H.); g10865013@cycu.edu.tw (F.S.)
3 Department of Applied Chemistry,
AuthorAffiliation_xml – name: 1 Department of Chemistry, Chung Yuan Christian University, Chung-Li 320314, Taiwan; g10765013@cycu.edu.tw (P.S.); hieubtn90@gmail.com (B.T.N.H.); g10701304@cycu.edu.tw (G.A.)
– name: 3 Department of Applied Chemistry, National Pingtung University, Pingtung 900391, Taiwan; kelvin@mail.nptu.edu.tw (K.H.-C.C.); hjc@mail.nptu.edu.tw (J.-C.H.)
– name: 4 Department of Aquatic Biosciences, National Chiayi University, 300 University Rd., Chiayi 60004, Taiwan; wwwtt333@gmail.com
– name: 6 Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila 1008, Philippines; reyarturo.tapia.fernandez@gmail.com
– name: 5 Faculty of Pharmacy and The Graduate School, University of Santo Tomas, Manila 1008, Philippines; mmroldan@ust.edu.ph
– name: 2 Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan; g10865014@cycu.edu.tw (M.E.S.); g10865016@cycu.edu.tw (K.A.K.); g10766011@cycu.edu.tw (F.S.); g10765017@cycu.edu.tw (A.H.); g10865013@cycu.edu.tw (F.S.)
– name: 7 Center for Nanotechnology, Chung Yuan Christian University, Chung-Li 320314, Taiwan
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33807713$$D View this record in MEDLINE/PubMed
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2021 by the authors. 2021
Copyright_xml – notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 3
Keywords Neocaridina denticulata
shrimp
cardiac activity
insecticide
locomotion activity
ecotoxicity
imidacloprid
Language English
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SSID ssj0000913809
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Snippet As a nicotinoid neurotoxic insecticide, imidacloprid (IMI) works by disrupting nerve transmission via nicotinic acetylcholine receptor (nAChR). Although IMI is...
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StartPage 391
SubjectTerms acetylcholine
Acetylcholine receptors (nicotinic)
Aquatic environment
cardiac activity
Energy metabolism
Experiments
Freshwater resources
Heart
heart rate
Imidacloprid
Immobilization
insecticide
Insecticides
Insects
Invertebrates
Locomotion
locomotion activity
Locomotor activity
Neocaridina denticulata
nerve tissue
Nervous system
Neurotoxicity
Neurotransmission
nicotinic receptors
Nontarget organisms
Oxidative metabolism
Oxidative stress
Pesticides
shrimp
Ventilation
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Title Exploiting the Freshwater Shrimp Neocaridina denticulata as Aquatic Invertebrate Model to Evaluate Nontargeted Pesticide Induced Toxicity by Investigating Physiologic and Biochemical Parameters
URI https://www.ncbi.nlm.nih.gov/pubmed/33807713
https://www.proquest.com/docview/2524418481
https://www.proquest.com/docview/2508574386
https://www.proquest.com/docview/2636460602
https://pubmed.ncbi.nlm.nih.gov/PMC7999401
https://doaj.org/article/ef015f9f5d3e4881b884f80e6e126523
Volume 10
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