GnRH receptors and peptides: Skating backward

Highlights • Tail-less type I GnRH receptors are in fishes, not just mammals. • Mammalian GnRH1, vertebrate GnRH2 and dogfish GnRH3 exist in cartilaginous skate. • GnRH3 peptides are found in cartilaginous and lobe finned fishes, not just teleosts. • The GnRH system emerged in early bilaterian evolu...

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Bibliographic Details
Published inGeneral and comparative endocrinology Vol. 209; pp. 118 - 134
Main Authors Roch, Graeme J, Busby, Ellen R, Sherwood, Nancy M
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2014
Subjects
Amino Acid Sequence
Animals
Bilateria
Branchiostoma lanceolatum
Cartilaginous GnRH1 peptide
Cartilaginous type I GnRH receptor
Endocrinology & Metabolism
Evolution, Molecular
Gene Deletion
GnRH synteny and phylogenetics
GnRHR superfamily
GnRHR synteny and phylogenetics
Gonadotropin-Releasing Hormone - classification
Gonadotropin-Releasing Hormone - genetics
Gonadotropin-Releasing Hormone - metabolism
Humans
Invertebrates - genetics
Marine
Phylogeny
Receptors, LHRH - genetics
Receptors, LHRH - metabolism
Reproduction - physiology
Vertebrates - genetics
Cartilaginous type I GnRH receptor
GnRH synteny and phylogenetics
Cartilaginous GnRH1 peptide
GnRHR synteny and phylogenetics
GnRHR superfamily
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Summary:Highlights • Tail-less type I GnRH receptors are in fishes, not just mammals. • Mammalian GnRH1, vertebrate GnRH2 and dogfish GnRH3 exist in cartilaginous skate. • GnRH3 peptides are found in cartilaginous and lobe finned fishes, not just teleosts. • The GnRH system emerged in early bilaterian evolution. • Early chordate evolution shaped a GnRH system resembling that of extant vertebrates.
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ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2014.07.025