Causal contribution and dynamical encoding in the striatum during evidence accumulation

A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterio...

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Bibliographic Details
Published ineLife Vol. 7
Main Authors Yartsev, Michael M, Hanks, Timothy D, Yoon, Alice Misun, Brody, Carlos D
Format Journal Article
LanguageEnglish
Published England eLife Sciences Publications Ltd 24.08.2018
eLife Sciences Publications, Ltd
Subjects
Action Potentials - physiology
Animals
Auditory pathways
Behavior
Behavior, Animal
Brain
Caudate-putamen
Clinical decision making
Computational neuroscience
Cortex (frontal)
Cortex (parietal)
Decision making
Estimates
Models, Neurological
Neostriatum
Neostriatum - physiology
Neural coding
Neural networks
Neurons
Neurons - physiology
Neuroscience
Neurosciences
Optogenetics
rat
Rats
Sensation
striatum
Task Performance and Analysis
United States > US
California
rat
striatum
neuroscience
decision making
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Summary:A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterior parietal cortex and the frontal orienting fields, may not be directly involved in this computation. Which, then, are the regions involved? Regions that are directly involved in evidence accumulation should directly influence the accumulation-based decision-making behavior, have a graded neural encoding of accumulated evidence and contribute throughout the accumulation process. Here, we investigated the role of the anterior dorsal striatum (ADS) in a rodent auditory evidence accumulation task using a combination of behavioral, pharmacological, optogenetic, electrophysiological and computational approaches. We find that the ADS is the first brain region known to satisfy the three criteria. Thus, the ADS may be the first identified node in the network responsible for evidence accumulation.
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These authors contributed equally to this work.
ISSN:2050-084X
2050-084X
DOI:10.7554/elife.34929