Noninvasive assessment of kidney dysfunction in children by using blood oxygenation level-dependent MRI and intravoxel incoherent motion diffusion-weighted imaging

• Published in: Insights into imaging Vol. 12; no. 1; p. 146
• Main Authors: Liang, Ping, Chen, Yaxian, Li, ShiChao, Xu, Chuou, Yuan, Guanjie, Hu, Daoyu, Kamel, Ihab, Zhang, Yu, Li, Zhen
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 21.10.2021; Springer Nature B.V; SpringerOpen
• Subjects: Biopsy; Blood; Blood oxygenation level-dependent magnetic resonance imaging; Children; Chronic kidney disease; Correlation coefficients; Creatinine; Diagnostic Radiology; Hospitals; Hypoxia; Imaging; Internal Medicine; Interventional Radiology; Intravoxel incoherent motion diffusion-weighted imaging; Kidney diseases; Magnetic resonance imaging; Mathematical analysis; Medical imaging; Medicine; Medicine & Public Health; Neuroradiology; Original; Original Article; Oxygenation; Parameters; Radiation; Radiology; Renal function; Statistical methods; Ultrasound; Chronic kidney disease; Children; Blood oxygenation level-dependent magnetic resonance imaging; Intravoxel incoherent motion diffusion-weighted imaging
• ISSN: 1869-4101; 1869-4101
• DOI: 10.1186/s13244-021-01091-6

Objectives To explore whether multiparametric approach including blood oxygenation level-dependent MRI (BOLD-MRI) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) can be applied in the assessment of renal function in children with chronic kidney disease (CKD). Materials and methods This prospective study included 74 children (CKD stage 1–3, 51; CKD stage 4–5, 12; healthy volunteers, 11) for renal MRI examinations including coronal T2WI, axial T1WI and T2WI, BOLD-MRI, and DWI sequences. We measured the renal cortex and medulla T2*, ADC, D t , D p , and f p values on BOLD and DWI images. Appropriate statistical methods were applied for comparing MRI-derived parameters among the three groups and calculating the correlation coefficients between MRI-derived parameters and clinical data. Receiver operating characteristic (ROC) curves were used to assess the diagnostic performance of MRI-derived parameters. Results There were significant differences in cortex T2*, ADC, D t , f p and medulla T2*, ADC, D t among the three groups. Cortex T2*, ADC, D t , f p and medulla T2*, ADC, D t had a trend: CKD stage 4–5 < CKD stage 1–3 < healthy volunteers. Cortex and medulla T2*, ADC, D t were significantly correlated with eGFR, serum creatinine (Scr), cystatin C. In addition, cortex T2* and eGFR showed the highest correlation coefficient ( r  = 0.824,  p  < 0.001). Cortex D t and medulla T2* were optimal parameters for differentiating healthy volunteers and CKD stage 1–3 or CKD stage 4–5 and CKD stage 1–3, respectively. Conclusions BOLD-MRI and IVIM-DWI might be used as a feasible method for noninvasive assessment of renal function in children with CKD.