The Anti-Cancer Mechanisms of Berberine: A Review

Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-re...

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Published inCancer management and research Vol. 12; pp. 695 - 702
Main Authors Wang, Ye, Liu, Yanfang, Du, Xinyang, Ma, Hong, Yao, Jing
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2020
Dove
Dove Medical Press
Subjects
anti-tumor
Antioxidants (Nutrients)
Apoptosis
Asian medicine
berberine
Cancer
Cancer metastasis
Cancer research
Cancer treatment
Cell cycle
Development and progression
Health aspects
Inflammation
MicroRNA
Proteins
Review
Telomerase
Traditional Chinese medicine
Tumors
China
anti-tumor
traditional Chinese medicine
cancer
berberine
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Summary:Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related proteins and signaling pathways. In addition, BBR inhibits cell proliferation by interacting with microRNAs and suppressing telomerase activity. BBR exerts its anti-inflammation and antioxidant properties, and also regulates tumor microenvironment. This review emphasized that BBR as a potential anti-inflammation and antioxidant agent, also as an effective immunomodulator, is expected to be widely used in clinic for cancer therapy.
Bibliography:ObjectType-Article-1
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These authors contributed equally to this work
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S242329