Dynamics and role of antibodies to Plasmodium falciparum merozoite antigens in children living in two settings with differing malaria transmission intensity

• Published in: Vaccine Vol. 34; no. 1; pp. 160 - 166
• Main Authors: Kangoye, David Tiga, Mensah, Victorine Atanase, Murungi, Linda Muthoni, Nkumama, Irene, Nebie, Issa, Marsh, Kevin, Cisse, Badara, Bejon, Philip, Osier, Faith Hope Among’in, Sirima, Sodiomon Bienvenu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 02.01.2016; Elsevier Limited; Elsevier Science
• Subjects: Allergy and Immunology; Antibodies, Protozoan - blood; Antibody dynamics; Antigens; Antigens, Protozoan - immunology; Burkina Faso - epidemiology; Child; Child, Preschool; Children & youth; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulins; Infant; Infants; Longitudinal Studies; Malaria; Malaria - epidemiology; Malaria - immunology; Malaria - transmission; Male; Medical research; Merozoite antigens; Merozoites - immunology; Parasites; Plasmodium falciparum; Plasmodium falciparum - immunology; Prospective Studies; Protective threshold; Rain; Senegal - epidemiology; Studies; Vaccines; Burkina Faso; Senegal; Protective threshold; Antibody dynamics; Infants; Merozoite antigens; Malaria
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2015.10.058

Highlights • Antibody dynamics and role in young the infants’ low susceptibility to febrile malaria were investigated. • No evidence for association of antibody titres with clinical protection was found. • Evidence for consistently low antibody titres in high and low transmission areas. • Other antibodies, other antibody-mediated mechanisms or other protecting factors may be operating.