Testing, diagnosis, and treatment following the implementation of a program to provide dried blood spot testing for HIV and hepatitis C infections: the NSW DBS Pilot

• Published in: BMC infectious diseases Vol. 24; no. 1; pp. 137 - 11
• Main Authors: Carrington, Nigel, Conway, Anna, Grebely, Jason, Starr, Mitchell, Catlett, Beth, Stevens, Annabelle, Prain, Bianca, McGrath, Colette, Causer, Louise, Guy, Rebecca, Holden, Joanne, Keen, Phillip, Kingsland, Melanie, Lu, Heng, Power, Cherie, Read, Phillip, Murray, Carolyn, McNulty, Anna, Cunningham, Philip
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.01.2024; BioMed Central; BMC
• Subjects: AIDS treatment; Analysis; Antibodies; Australian aborigines; Blood; Cohort Studies; Control; Dried blood spot; Dried Blood Spot Testing - methods; Drug use; Drugs; Effectiveness; Feasibility studies; Female; Health aspects; Health care; Health services; Hepacivirus - genetics; Hepatitis; Hepatitis C; Hepatitis C - diagnosis; Hepatitis C - drug therapy; Hepatitis C virus; HIV; HIV Antibodies; HIV Infections - diagnosis; HIV Infections - drug therapy; HIV testing; HIV-1 - genetics; Homosexuality, Male; Human immunodeficiency virus; Humans; Identification and classification; Implementation; Infections; Male; Medical research; Medical tests; Men; Models of care; Native peoples; New South Wales; Non-binary gender; Patient outcomes; Populations; Postal services; Prisons; Registration; Regression analysis; Research ethics; Ribonucleic acid; RNA; RNA, Viral; Sensitivity and Specificity; Sexual and Gender Minorities; Sexually transmitted diseases; Social aspects; Spot testing; STD; Testing; Testing laboratories; Venous access; New South Wales; Australia; Southeast Asia; Asia; Africa; Torres Strait; Sub-Saharan Africa; New South Wales Australia; Models of care; HIV; Hepatitis C; Dried blood spot; Implementation; Testing
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-024-08989-8

Dried blood spot (DBS) testing provides an alternative to phlebotomy and addresses barriers to accessing healthcare experienced by some key populations. Large-scale evaluations of DBS testing programs are needed to understand their feasibility. This study evaluated the implementation of a state-wide DBS HIV and hepatitis C virus (HCV) testing pilot. The New South Wales (NSW) DBS Pilot is an interventional cohort study of people testing for HIV antibody and/or HCV RNA from DBS samples in NSW, Australia. Participants at risk of HIV/HCV participated in testing via: 1) self-registration online with a DBS collection kit delivered and returned by conventional postal service; or 2) assisted DBS sample collection at 36 community health sites (including drug treatment and harm-minimisation services) and prisons. Participants received results by text (HIV antibody/ HCV RNA not detected) or a healthcare provider (HIV antibody/ HCV RNA detected). The RE-AIM framework was used to evaluate reach, effectiveness, adoption, and implementation. Reach: Between November 2016 and December 2020, 7,392 individuals were tested for HIV and/or HCV (21% self-registration, 34% assisted in community, and 45% assisted in prison). Of 6,922 people tested for HIV (19% men who have sex with men, 13% living outside major cities, 21% born outside Australia), 51% (3,521/6,922) had no HIV test in the past two years, 0.1% (10/6,922) were newly diagnosed with HIV, and 80% (8/10) initiated HIV treatment within six months. Of 5,960 people tested for HCV (24% women, 35% Aboriginal and/or Torres Strait Islander, 55% recently injected drugs), 15% had detectable HCV RNA (878/5,960), and 45% (393/878) initiated treatment within six months. Adoption: By the end of 2020, DBS via assisted registration was available at 36 community sites and 21 prisons. 90% of DBS cards arriving at the laboratory had the three full spots required for testing; the proportion was higher in assisted (94%) compared to online (76%) registration. This study demonstrated the feasibility of DBS testing for HIV and HCV in key populations including Aboriginal and Torres Strait Islander peoples, men who have sex with men, people who inject drugs, and demonstrated the utility of DBS in the prison setting.