Isotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general population

• Published in: Journal of clinical virology Vol. 43; no. 3; pp. 317 - 322
• Main Authors: Matsunaga, Hidenori, Tanaka, Susumu, Fukumori, Akio, Tomonaga, Keizo, Ikuta, Kazuyoshi, Amino, Nobuyuki, Takeda, Masatoshi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.11.2008; Elsevier Science
• Subjects: Adult; Aged; Allergy and Immunology; Antibodies, Viral - blood; Antibody Affinity; Antigens, Viral - immunology; Biological and medical sciences; Borna Disease - epidemiology; Borna Disease - immunology; Borna disease virus; Borna disease virus - immunology; Female; Fundamental and applied biological sciences. Psychology; Human viral diseases; Humans; Immature immune response; Immunoglobulin A - blood; Immunoglobulin G - blood; Immunoglobulin M - blood; Infectious Disease; Infectious diseases; Japan - epidemiology; Low avidity IgG; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Mucosal involvement; Persistent IgM; Viral diseases; Virology; Japan; Immature immune response; Persistent IgM; Borna disease virus; Low avidity IgG; Mucosal involvement; Bornavirus; Human; Immune response; Microbiology; Antibody; Mucosa; IgG; Isotype; Bornaviridae; IgM; Virology; Virus; Mononegavirales; Avidity
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/j.jcv.2008.07.011

Borna disease virus (BDV) infection of humans has not been widely accepted due to the low titer of the antibody and lack of reliable diagnostic tools. To examine exposure to BDV or a related virus in Japanese psychiatric and general population by detecting the specific IgG, IgM, and IgA. Sera from 304 psychiatric and 378 control subjects were examined for IgG, IgM, and IgA against BDV nucleoprotein (N) and phosphoprotein (P) using highly specific and sensitive radioligand assay. The avidity was also examined. The specific IgG, IgM, and IgA against both BDV-N and -P were detected and the seropositivity was not significantly different between patients and controls. The avidity of the specific IgG was low to moderate, and the specific IgM did not disappear for several years. Our results suggested common exposure to BDV or a related virus in the general Japanese population. Low avidity IgG and persistent IgM suggested delayed immune response against BDV or a related virus. The specific IgA indicated mucosal involvement.