ABO, Lewis blood group systems and secretory status with H.pylori infection in yemeni dyspeptic patients: a cross- sectional study

• Published in: BMC infectious diseases Vol. 23; no. 1; p. 520
• Main Authors: Almorish, Mohammed Abdulwahid, Al-Absi, Boshra, Elkhalifa, Ahmed M E, Elamin, Elham, Elderdery, Abozer Y, Alhamidi, Abdulaziz H
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.08.2023; BioMed Central; BMC
• Subjects: ABO; ABO Blood-Group System - genetics; ABO system; Antibodies; Antigens; Blood groups; Chromatography; Cross-Sectional Studies; Developing countries; Diagnosis; Disease susceptibility; Dyspepsia; Dyspepsia - epidemiology; Endoscopy; Female; Females; Gastric cancer; H.pylori; Health aspects; Helicobacter Infections; Helicobacter pylori; Hemagglutination inhibition; Humans; Immunoassay; Infection; Infections; Infectious diseases; LDCs; Lewis; Lewis Blood Group Antigens - genetics; Male; Males; Medical research; Medicine, Experimental; Monoclonal antibodies; Phenotype; Phenotypes; Risk factors; Saliva; Secretor; Sex differences; Statistical analysis; Ulcers; China; Yemen; Saudi Arabia; United Kingdom > UK; Le; H.pylori; Lewis; ABO; Secretor
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-023-08496-2

The ABO and Lewis blood group antigens are potential factors in susceptibility to H. pylori infection. This research aimed to examine the prevalence of Helicobater pylori (H.pylori) infection and its association with ABO, Lewis blood group systems, and secretory status in Yemeni symptomatic patients. In a cross-sectional study, 103 patients referred for endoscopy due to dyspepsia were included. H pylori infection was assessed using stool antigen and serum antibody rapid tests. ABO and Lewis blood group systems were examined using hemagglutination assay. Saliva samples were investigated for identification of the secretory phenotype using hemagglutination inhibition test. The prevalence of H. pylori infection was (80.6%), with a higher rate of infection in females than males. The ABO blood groups were found to be significantly different between males and females (p = 0.047). The O blood group was prevalent among H. pylori patients, especially secretors. There was a significant association between ABO blood groups and H. pylori infection (p = 0.001). The Le (a + b+) phenotype was the most common, followed by Le (a + b-), Le (a-b+), and Le (a-b-). Lewis blood group systems and secretory status of symptomatic patients were not associated with H. pylori infection. The results showed that serum Ab test for H. pylori achieved poor sensitivity (68%), specificity of 55%; positive predictive value (PPV) 86%, negative predictive value (NPV) 29% and accuracy 65.1%. The prevalence of H. pylori infection was high in Yemeni patients. This infection was linked to the O and Le (a + b+) secretor phenotype. The H. pylori stool Ag test is the most reliable noninvasive diagnostic method for detecting H. pylori infection.