Overview of microRNA-199a Regulation in Cancer

microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional s...

Full description

Saved in:
Bibliographic Details
Published inCancer management and research Vol. 11; pp. 10327 - 10335
Main Authors Wang, Qiwen, Ye, Bingyu, Wang, Ping, Yao, Fenjie, Zhang, Chunyan, Yu, Guoying
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.12.2019
Dove
Dove Medical Press
Subjects
Apoptosis
biomarker
Cancer
Cancer cells
Cancer research
Carcinoma
Development and progression
Genes
Genetic aspects
Homeostasis
MicroRNA
microrna-199a
Physiological aspects
regulatory mechanisms
Review
target genes
Transcription (Genetics)
Vincristine
China
regulatory mechanisms
biomarker
target genes
carcinoma
microRNA-199a
Online AccessGet full text

Cover

More Information
Summary:microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR-199a and review recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors contributed equally to this work
ISSN:1179-1322
1179-1322
DOI:10.2147/cmar.s231971