Maternal age-related differential global expression profiles observed in human oocytes

Abstract The age-related decline in female fertility has been attributed to a variety of causes including progressive oocyte depletion, meiotic irregularities and mitochondrial dysfunction. However, additional factors could potentially be involved. To explore this possibility, comprehensive analysis...

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Published inReproductive biomedicine online Vol. 14; no. 6; pp. 700 - 708
Main Authors Steuerwald, Nury M, Bermúdez, Mercedes G, Wells, Dagan, Munné, Santiago, Cohen, Jacques
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 2007
Subjects
Adult
Age Factors
ageing
Cluster Analysis
Down-Regulation
Female
gene expression
Gene Expression Profiling
human oocytes
Humans
Maternal Age
microarray
Obstetrics and Gynecology
Oligonucleotide Array Sequence Analysis
Oocytes - physiology
RNA
Up-Regulation
ageing
microarray
RNA
human oocytes
gene expression
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Summary:Abstract The age-related decline in female fertility has been attributed to a variety of causes including progressive oocyte depletion, meiotic irregularities and mitochondrial dysfunction. However, additional factors could potentially be involved. To explore this possibility, comprehensive analysis of gene expression in human oocytes, discarded following IVF procedures and segregated by age, was undertaken using microarray methods. These findings indicate that the expression of oocyte genes, in a variety of major functional categories including cell cycle regulation, cytoskeletal structure, energy pathways, transcription control, and stress responses, are influenced by maternal age. These results are corroborated by a complementary extensive study using mouse oocytes.
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ISSN:1472-6483
1472-6491
DOI:10.1016/S1472-6483(10)60671-2