High-glucose environment disturbs the physiologic functions of keratinocytes: Focusing on diabetic wound healing

Abstract Impaired wound healing is a common and potentially serious complication in patients with diabetes. In recent years, disturbed physiologic functions of epidermal keratinocytes have been found to play a central role in the poor healing ability of diabetic wounds. Factors involving keratinocyt...

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Published inJournal of dermatological science Vol. 84; no. 2; pp. 121 - 127
Main Authors Hu, Stephen Chu-Sung, MBBS, M.Phil, Lan, Cheng-Che E., MD, PhD
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.2016
Subjects
Animals
Cell Movement
Cell Proliferation
Dermatology
Diabetes
Diabetes Mellitus - drug therapy
Diabetes Mellitus - metabolism
Epidermis - metabolism
Gap Junctions - metabolism
Glucose - chemistry
Hemostasis
High-glucose environment
Humans
Immunity, Innate
Inflammation
Keratinocytes
Keratinocytes - cytology
Keratinocytes - drug effects
Matrix Metalloproteinases - metabolism
Mice
Oxidative Stress
Wound healing
Wound Healing - physiology
Keratinocytes
High-glucose environment
Wound healing
Diabetes
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Summary:Abstract Impaired wound healing is a common and potentially serious complication in patients with diabetes. In recent years, disturbed physiologic functions of epidermal keratinocytes have been found to play a central role in the poor healing ability of diabetic wounds. Factors involving keratinocytes that may contribute to the dysfunctional wound healing process in diabetes include impaired keratinocyte migration and proliferation, gap junction abnormalities, chronic inflammation, chronic infections associated with defective innate immunity, impaired angiogenesis, increased oxidative stress, and abnormal expression of matrix metalloproteinases (MMPs). In this review article, we provide evidence from the scientific literature for the molecular mechanisms of delayed wound healing in diabetes, with particular emphasis on keratinocytes. Elucidating the spectrum of molecular and functional abnormalities in keratinocytes induced by high-glucose environment may lead to more effective and individualized therapeutic strategies for the prevention and management of chronic diabetic wounds.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2016.07.008