Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair

Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules...

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Published ineLife Vol. 5
Main Authors Barreiro, Olga, Cibrian, Danay, Clemente, Cristina, Alvarez, David, Moreno, Vanessa, Valiente, Íñigo, Bernad, Antonio, Vestweber, Dietmar, Arroyo, Alicia G, Martín, Pilar, von Andrian, Ulrich H, Sánchez Madrid, Francisco
Format Journal Article
LanguageEnglish
Published England eLife Sciences Publications Ltd 15.06.2016
eLife Sciences Publications, Ltd
Subjects
Animals
Antigens
Bone marrow
Cloning
Genotoxicity
Homeostasis
Immunology
Inflammation
intravital imaging
Macromolecules
Macrophages
Macrophages - classification
Macrophages - physiology
Mice
Nanoparticles
Osteoprogenitor cells
Pathogens
Rodents
Skin
Skin - cytology
Skin - immunology
Specialization
Transcription
Wound healing
mouse
macrophages
wound healing
immunology
intravital imaging
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Summary:Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1(+) progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis.
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Department of Microbiology and Immunobiology, Harvard Medical School, Boston, United States.
ISSN:2050-084X
2050-084X
DOI:10.7554/elife.15251