Improvement of BCG protective efficacy with a novel chimpanzee adenovirus and a modified vaccinia Ankara virus both expressing Ag85A

• Published in: Vaccine Vol. 33; no. 48; pp. 6800 - 6808
• Main Authors: Stylianou, E, Griffiths, K.L, Poyntz, H.C, Harrington-Kandt, R, Dicks, M.D, Stockdale, L, Betts, G, McShane, H
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 27.11.2015; Elsevier Limited; Elsevier Science
• Subjects: Acyltransferases - genetics; Acyltransferases - immunology; Adenoviridae; Adenovirus; Adenoviruses, Simian - genetics; Allergy and Immunology; Animals; Antigens; Antigens, Bacterial - genetics; Antigens, Bacterial - immunology; BCG; Clinical trials; Disease Models, Animal; Drug Carriers; Experiments; Female; Genetic Vectors; Immunization Schedule; Immunogenicity; Infections; Intranasal; Lungs; Mice, Inbred BALB C; Mycobacterium tuberculosis; Pan troglodytes; Protection; Studies; Treatment Outcome; Tuberculosis; Tuberculosis - prevention & control; Tuberculosis Vaccines - administration & dosage; Tuberculosis Vaccines - genetics; Tuberculosis Vaccines - immunology; Vaccine; Vaccines; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - genetics; Vaccines, Attenuated - immunology; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Vaccinia virus - genetics; Vectors (Biology); Viral vector; United Kingdom > UK; Turkey, Ankara; Tuberculosis; Intranasal; Viral vector; Immunogenicity; BCG; Vaccine; Protection
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2015.10.017

Highlights • Intranasal immunisation with ChAdOx1.85A induces strong T-cell responses. • ChAdOx1.85A boosted with MVA85A significantly improves the protective efficacy of BCG. • MVA85A boost is protective both after mucosal and systemic administration.