First Total Synthesis of Neoantimycin

The first total synthesis of neoantimycin (1), an unusual ring-extended antibiotic of the antimycin class, has been achieved, using intramolecular transesterification for construction of the 15-membered tetralactone core.

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Bibliographic Details
Published inChemistry letters Vol. 44; no. 9; pp. 1214 - 1216
Main Authors Ogawa, Hikaru, Iio, Hideo, Usuki, Yoshinosuke
Format Journal Article
LanguageEnglish
Published TOKYO Chemical Soc Japan 2015
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
PRUNUSTATIN-A
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Summary:The first total synthesis of neoantimycin (1), an unusual ring-extended antibiotic of the antimycin class, has been achieved, using intramolecular transesterification for construction of the 15-membered tetralactone core.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.150509