Increased fetal heart rate variability in periventricular leukomalacia

• Published in: Brain & development (Tokyo. 1979) Vol. 38; no. 2; pp. 196 - 203
• Main Authors: Kurahashi, Hirokazu, Okumura, Akihisa, Kubota, Tetsuo, Kidokoro, Hiroyuki, Maruyama, Koichi, Hayakawa, Masahiro, Itakura, Atsuo, Matsuzawa, Katsuji, Yamamoto, Hiroyuki, Kato, Toru, Hayakawa, Fumio, Watanabe, Kazuyoshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2016
• Subjects: Fast Fourier transform; Female; Fetal heart rate; Gestational Age; Heart Rate, Fetal - physiology; Humans; Infant; Infant, Newborn; Infant, Premature; Leukomalacia, Periventricular - physiopathology; Long-term variability; Male; Neurology; Periventricular leukomalacia; Pregnancy; Risk Factors; Fetal heart rate; Periventricular leukomalacia; Long-term variability; Fast Fourier transform
• ISSN: 0387-7604; 1872-7131
• DOI: 10.1016/j.braindev.2015.08.008

Abstract Objective This study used quantitative analysis to determine whether increased variability in fetal heart rate (FHR) is related to the risk of developing periventricular leukomalacia (PVL). Methods We analyzed 124 FHR traces of neonates delivered preterm at 27–33 weeks’ gestation to 105 mothers. FHR traces 1–3 h before delivery were translated into power-spectrum curves using a fast Fourier transformation. The total power (the area under the curve of 1–10 cycles per minute), segmental power of every cycle per minute, peak power, and frequency edges were calculated, and their relationship with the subsequent development of PVL was examined. Results Total power was significantly higher in the PVL group ( n = 9, median 1813, range 1064–2426) compared to the non-PVL group ( n = 114, median 1383, range 381–3324, p = 0.029). Infants in the PVL group had greater segmental power in segments with 1–2, 2–3, and 9–10 cycles per minute, than those in the non-PVL group. Total power of ⩾1550 was significantly correlated with the subsequent development of PVL and premature rupture of membranes. Furthermore, the frequency of pregnancy-induced hypertension was significantly reduced in the fetuses with a total power of ⩾1550. Conclusion Our study suggests that a fetus with increased FHR variability is at risk of developing PVL. This study provides additional evidence supporting the contribution of antenatal factors to the subsequent development of PVL.