Biological significance of agmatine, an endogenous ligand at imidazoline binding sites

Many publications have shown that imidazoline derivatives such as clonidine, moxonidine or rilmenidine reduce sympathetic tone via a central mechanism and that as a result they reduce plasma catecholamines and blood pressure. This reduction in blood pressure appears not to be regulated via periphera...

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Bibliographic Details
Published inBritish journal of pharmacology Vol. 133; no. 6; pp. 755 - 780
Main Authors Raasch, Walter, Schäfer, Ulrich, Chun, Julian, Dominiak, Peter
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.07.2001
Nature Publishing
Subjects
agmatine
Agmatine - metabolism
Agmatine - pharmacology
Animals
Antihypertensive agents
Binding Sites
Binding, Competitive
Biological and medical sciences
blood pressure
Blood Pressure - drug effects
Cardiovascular system
CDS
Cell receptors
Cell structures and functions
Clonidine - analogs & derivatives
Clonidine - metabolism
Fundamental and applied biological sciences. Psychology
gastric acid
growth effects
Heart Rate - drug effects
Humans
Imidazoles - metabolism
imidazoline
Imidazoline binding site
insulin secretion
Ligands
Medical sciences
Miscellaneous
Molecular and cellular biology
neuroprotection
Pharmacology. Drug treatments
renal effects
Review
Agonist
Central nervous system
Neuroprotective agent
Glutamate receptor
Binding site
Metabolism
Sympathetic nervous system
Insulin
Biological activity
Kidney
Imidazoline receptor
Biological fixation
Urinary system
Antihypertensive agent
Arterial pressure
Exocrine secretion
NMDA receptor
Agmatine
Bibliographic review
Brain (vertebrata)
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Summary:Many publications have shown that imidazoline derivatives such as clonidine, moxonidine or rilmenidine reduce sympathetic tone via a central mechanism and that as a result they reduce plasma catecholamines and blood pressure. This reduction in blood pressure appears not to be regulated via peripheral, presynaptically localized receptors, since neither catecholamine depletion by reserpine, or since neither catecholamine destruction of the nerve endings with 6-hydroxydopamine produces a notable weakening of the clonidine-induced blood pressure reduction.
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ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0704153