Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus

• Published in: Nature neuroscience Vol. 23; no. 2; pp. 217 - 228
• Main Authors: Gao, Claire, Leng, Yan, Ma, Jun, Rooke, Victoria, Rodriguez-Gonzalez, Shakira, Ramakrishnan, Charu, Deisseroth, Karl, Penzo, Mario A.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2020; Nature Publishing Group
• Subjects: 631/378/1457/1945; 631/378/3920; Animal Genetics and Genomics; Animals; Arousal; Arousal (Physiology); Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain research; Cerebral cortex; Cortex (somatosensory); Female; Functional morphology; Gene expression; Genetic aspects; Male; Mice; Mice, Inbred C57BL; Motivation; Neural Pathways - cytology; Neural Pathways - physiology; Neurobiology; Neurons; Neurons - cytology; Neurons - physiology; Neurosciences; Paraventricular Hypothalamic Nucleus - cytology; Paraventricular Hypothalamic Nucleus - physiology; Paraventricular nucleus; Physiological aspects; Prefrontal cortex; Thalamus; United States
• ISSN: 1097-6256; 1546-1726
• DOI: 10.1038/s41593-019-0572-3

Unlike the sensory thalamus, studies on the functional organization of the midline and intralaminar nuclei are scarce, and this has hindered the establishment of conceptual models of the function of this brain region. We investigated the functional organization of the paraventricular nucleus of the thalamus (PVT), a midline thalamic structure that is increasingly being recognized as a critical node in the control of diverse processes such as arousal, stress, emotional memory and motivation, in mice. We identify two major classes of PVT neurons—termed type I and type II—that differ in terms of gene expression, anatomy and function. In addition, we demonstrate that type II neurons belong to a previously neglected class of PVT neurons that convey arousal-related information to corticothalamic neurons of the infralimbic cortex. Our results uncover the existence of an arousal-modulated thalamo-corticothalamic loop that links the PVT and the ventromedial prefrontal cortex. Gao et al. provide evidence that two major classes of neurons exist in the paraventricular thalamus. One of these, termed type II PVT neurons, belongs to a previously ignored cell population that relays arousal information to the infralimbic cortex.