Regional Cerebral Blood Flow in [123]I-IMP Single-photon Emission Computed Tomography and the Wechsler Memory Scale-revised in Nondemented Elderly Subjects with Subjective Cognitive Impairment

• Published in: Internal Medicine Vol. 55; no. 24; pp. 3571 - 3578
• Main Authors: Niwa, Fumitoshi, Imanishi, Jiro, Sakurada, Kumi, Nakagawa, Masanori, Kondo, Masaki, Mizuno, Toshiki
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2016
• Subjects: Aged; Cerebral Cortex - blood supply; Cerebral Cortex - diagnostic imaging; Cerebrovascular Circulation; Cognition Disorders - diagnostic imaging; Cognition Disorders - physiopathology; Cognition Disorders - psychology; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - physiopathology; Cognitive Dysfunction - psychology; Dementia - diagnosis; Female; Humans; Iodine Radioisotopes; left inferior frontal gyrus (LIFG); Male; Middle Aged; Neuropsychological Tests; Original; single-photon emission computed tomography (SPECT); subjective cognitive impairment (SCI); Temporal Lobe - blood supply; Temporal Lobe - diagnostic imaging; Tomography, Emission-Computed, Single-Photon; visual memory; wechsler Memory Scale (WMS)
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.55.6725

Objective Regional cerebral blood flow (rCBF) imaging with single-photon emission computed tomography (SPECT) is useful in the early diagnosis of dementia. We aimed to investigate the association between the rCBF and various domains related to the memory function in elderly subjects with subjective cognitive impairment (SCI). Methods Thirty-two subjects with SCI were included in the present study. Patients with dementia and mild cognitive impairment (MCI) were excluded based on the presence of logical memory impairment. N-isopropyl-p-[123I]-iodoamphetamine SPECT was performed and Wechsler Memory Scale-Revised (WMS-R) was administered to all subjects (mean age, 68.4 years; average Mini-Mental State Examination score, 27.6). The SPECT results were analyzed using the easy Z-score imaging system and the voxel-based stereotactic extraction estimation method. Correlation analyses were performed to investigate the correlation between the mean positive Z-scores in the decrease of the rCBF and the WMS-R indices. Results The SPECT study indicated marked hypoperfusion in some areas, including the bilateral temporal areas, the caudate, and the thalamus, in these subjects in comparison to the normal database. The decrease in the rCBF that was observed in several regions, including the left precuneus and left inferior frontal gyrus (LIFG), showed a significant negative correlation with several indices of the memory function, particularly visual memory. Conclusion The regional hypoperfusion observed in the study using the voxel-based stereotactic extraction estimation method suggest that the regional cerebral dysfunction is associated with the memory function of patients with SCI, even though the subjects in the present study were cognitively intact. The correlation analysis with the WMS-R suggested the contribution of the LIFG to the memory function and indicated the significance of visual memory dysfunction in the neuropsychological assessment to determine the stage of SCI.