Protein degradation systems in platelets

Protein synthesis and degradation are essential processes that allow cells to survive and adapt to their surrounding milieu. In nucleated cells, the degradation and/or cleavage of proteins is required to eliminate aberrant proteins. Cells also degrade proteins as a mechanism for cell signalling and...

Full description

Saved in:
Bibliographic Details
Published inThrombosis and haemostasis Vol. 110; no. 5; p. 920
Main Authors Kraemer, B F, Weyrich, A S, Lindemann, S
Format Journal Article
LanguageEnglish
Published Germany 01.11.2013
Subjects
Animals
Blood Platelets - metabolism
Cysteine Proteases - metabolism
Humans
Proteasome Endopeptidase Complex - metabolism
Proteolysis
Signal Transduction
calpain
proteasome
Platelets
protein degradation
Online AccessGet more information

Cover

More Information
Summary:Protein synthesis and degradation are essential processes that allow cells to survive and adapt to their surrounding milieu. In nucleated cells, the degradation and/or cleavage of proteins is required to eliminate aberrant proteins. Cells also degrade proteins as a mechanism for cell signalling and complex cellular functions. Although the last decade has convincingly shown that platelets synthesise proteins, the roles of protein degradation in these anucleate cytoplasts are less clear. Here we review what is known about protein degradation in platelets placing particular emphasis on the proteasome and the cysteine protease calpain.
ISSN:0340-6245
DOI:10.1160/TH13-03-0183