Small changes in expression affect predisposition to tumorigenesis

We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

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Bibliographic Details
Published inNature genetics Vol. 30; no. 1; pp. 25 - 26
Main Authors Vogelstein, Bert, Yan, Hai, Dobbie, Zuzana, Gruber, Stephen B, Markowitz, Sanford, Romans, Kathy, Giardiello, Francis M, Kinzler, Kenneth W
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 01.01.2002
Subjects
Adenoma - genetics
adenomatous polyposis coli
Adenomatous Polyposis Coli - genetics
Alleles
APC gene
Biological and medical sciences
Cancer
Cell Transformation, Neoplastic - genetics
Disease
DNA, Complementary - genetics
DNA, Neoplasm - genetics
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation
Genes, APC
Genes. Genome
Genetic aspects
Genetic disorders
Genetic Predisposition to Disease
Humans
Loss of Heterozygosity
Molecular and cellular biology
Molecular genetics
Physiological aspects
Polymerase Chain Reaction
Proteins
Ratios
Templates, Genetic
Tumor suppressor genes
Tumors
United States
United States > US
Allele
Predisposition
Development
Lead
Familial adenomatous polyposis coli
Gene expression
Carcinogenesis
Tumor suppressor gene
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Summary:We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.
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ISSN:1061-4036
1546-1718
DOI:10.1038/ng799