A Convenient Preparation of Salicylaldehydes from 2-Methylbenzofurans by Ozonolysis

A convenient and effective transformation of 2-methylbenzofuran (B) to salicylaldehyde (C) was achieved by ozonolysis of B in CH2Cl2 at -78°C followed by alkaline hydrolysis.

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Bibliographic Details
Published inChem. Pharm. Bull Vol. 41; no. 6; pp. 1166 - 1168
Main Authors ISHII, Hisashi, OHTA, Shuji, NISHIOKA, Hiromi, HAYASHIDA, Naomi, HARAYAMA, Takashi
Format Journal Article
LanguageEnglish
Published TOKYO The Pharmaceutical Society of Japan 1993
公益社団法人日本薬学会
Pharmaceutical Soc Japan
Maruzen
Japan Science and Technology Agency
Subjects
2-methylbenzofuran
benzofuran ring cleavage
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Exact sciences and technology
Life Sciences & Biomedicine
Noncondensed benzenic compounds
Organic chemistry
osmium tetroxide
ozonolysis
Pharmacology & Pharmacy
Physical Sciences
Preparations and properties
ruthenium tetroxide
salicylaldehyde
Science & Technology
OZONOLYSIS
BENZOFURAN RING CLEAVAGE
2-METHYLBENZOFURAN
SALICYLALDEHYDE
RUTHENIUM TETROXIDE
OSMIUM TETROXIDE
Aldehydophenols
Ozonolysis
Benzenic compound
Ether
Benzaldehyde derivatives
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Summary:A convenient and effective transformation of 2-methylbenzofuran (B) to salicylaldehyde (C) was achieved by ozonolysis of B in CH2Cl2 at -78°C followed by alkaline hydrolysis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.41.1166