Liquid chromatography-tandem mass spectrometry method for simultaneous determination of albendazole and albendazole sulfoxide in human plasma for bioequivalence studies

• Published in: Journal of pharmaceutical analysis Vol. 6; no. 4; pp. 226 - 234
• Main Authors: Rathod, Dhiraj M., Patel, Keyur R., Mistri, Hiren N., Jangid, Arvind G., Shrivastav, Pranav S., Sanyal, Mallika
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.08.2016; Department of Chemistry, Kadi Sarv%Bioanalytical Research Department, Accutest Research Lab, Bodakdev, Ahmedabad 380059, India%Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380009, India%Department of Chemistry, St. Xavier's Col ege, Navrangpura, Ahmedabad 380009, India; Xi'an Jiaotong University; Elsevier
• Subjects: Albendazole; Albendazole sulfoxide; Bioequivalence study; LC > MS/MS; Original; Solid phase extraction; 丙硫咪唑; 亚砜; 人血浆; 同时测定; 液相色谱-串联质谱法; 生物等效性; 阿苯达唑; 高效液相色谱-串联质谱; Solid phase extraction; Bioequivalence study; Albendazole; LC > MS/MS; Albendazole sulfoxide; LC-MS/MS

An improved high performance liquid chromatography-tandem mass spectrometry（LC-MS/MS） method has been developed for sensitive and rapid determination of albendazole（ABZ） and its active metabolite,albendazole sulfoxide（ABZSO）,in the positive ionization mode.The method utilized solid phase extraction（...