Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD

• Published in: Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 46; no. 5; pp. 348 - 350
• Main Authors: Ouyang, Yeyun, Bott, Alex J., Rutter, Jared
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2021
• Subjects: Animals; Biological Transport; mammals; mitochondria; Mitochondria - metabolism; Mitochondrial Membrane Transport Proteins - metabolism; mitochondrial transporter; NAD; Nitrazepam - metabolism; redox; respiration; SLC25A family; solutes; NAD; SLC25A family; respiration; mitochondrial transporter; redox

Recently, three groups, Girardi et al., Kory et al., and Luongo et al., independently identified solute carrier (SLC) 25A51 as the long-sought, major mitochondrial NAD+ transporter in mammalian cells. These studies not only deorphan an uncharacterized transporter of the SLC25A family, but also shed...