Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD

Recently, three groups, Girardi et al., Kory et al., and Luongo et al., independently identified solute carrier (SLC) 25A51 as the long-sought, major mitochondrial NAD+ transporter in mammalian cells. These studies not only deorphan an uncharacterized transporter of the SLC25A family, but also shed...

Full description

Saved in:
Bibliographic Details
Published inTrends in biochemical sciences (Amsterdam. Regular ed.) Vol. 46; no. 5; pp. 348 - 350
Main Authors Ouyang, Yeyun, Bott, Alex J., Rutter, Jared
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.05.2021
Subjects
Animals
Biological Transport
mammals
mitochondria
Mitochondria - metabolism
Mitochondrial Membrane Transport Proteins - metabolism
mitochondrial transporter
NAD
Nitrazepam - metabolism
redox
respiration
SLC25A family
solutes
NAD
SLC25A family
respiration
mitochondrial transporter
redox
Online AccessGet full text

Cover

More Information
Summary:Recently, three groups, Girardi et al., Kory et al., and Luongo et al., independently identified solute carrier (SLC) 25A51 as the long-sought, major mitochondrial NAD+ transporter in mammalian cells. These studies not only deorphan an uncharacterized transporter of the SLC25A family, but also shed light on other aspects of NAD+ biology.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2021.02.001